Antibacterial properties of cerium oxide nanoparticles: Recent progresses and future challenges (Open Access)--颗粒学报PARTICUOLOGY

Zheng, H., Tang, J., Wei, Y., Deng, X., Zhang, Y., Ma, X., . . . Liao, H. (2024). Antibacterial properties of cerium oxide nanoparticles: Recent progresses and future challenges. Particuology, 93, 264-283. https://doi.org/10.1016/j.partic.2024.06.017

Antibacterial properties of cerium oxide nanoparticles: Recent progresses and future challenges (Open Access)

Heishu Zheng^{a b}, Jiajing Tang^{a b}, Yanhua Wei^{a b}, Xi Deng^c, Yingjuan Zhang^{a b}, Xiangyu Ma^{a b}, Xudong Jiang^d, Zhi Ping Xu^{e f *}, Hongbing Liao^{a b *}

a College & Hospital of Stomatology, Guangxi Medical University, Nanning, 530021, China
b Guangxi Key Laboratory of Oral and Maxillofacial Rehabilitation and Reconstruction, Guangxi Medical University, Nanning, 530021, China
c The First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, China
d School of Medicine, Guangxi University of Science and Technology, Liuzhou, 545005, China
e Institute of Biomedical Health Technology and Engineering and Institute of Systems and Physical Biology, Shenzhen Bay Laboratory, Shenzhen, 518107, China
f Australian Institute for Bioengineering and Nanotechnology (Bld 75), The University of Queensland, St Lucia, Queensland 4074, Australia

10.1016/j.partic.2024.06.017

Volume 93, October 2024, Pages 264-283

Received 22 March 2024, Revised 8 June 2024, Accepted 28 June 2024, Available online 14 July 2024, Version of Record 22 July 2024.

E-mail: gordonxu@uq.edu.au; hongbing_liao@gxmu.edu.cn

Highlights

• Details of control preparation, crystal structure and property of typical cerium oxide nanoparticles.

• Summary of antibacterial mechanisms of cerium oxide nanoparticles.

• Proposed strategies for improving the antibacterial ability of cerium oxide nanoparticles.

• Proposed principle for applications of cerium oxide nanoparticles in clinical settings.

Abstract

Use of cerium oxide nanoparticles (CeO₂ NPs) to optimize management of resistant microorganisms has received increasing attention due to non-specific activity of inorganic antibacterial agents. Understanding the mechanism of action is essential to elucidating the antibacterial activity of CeO₂ NPs against bacteria. Therefore, this review aims to summarize the antibacterial mechanisms of CeO₂ NPs and correlate the structural and physicochemical properties of CeO₂ NPs to their antibacterial activity. We further summarize the strategies for the improvement of the antibacterial performance of CeO₂ NPs and provide our opinions for future challenges as a conclusion.

Graphical abstract

Keywords

Nanoparticles; Cerium oxide; Antibacterial activity; Nanozyme; Fenton reaction

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