Understanding the mechanical properties of single micro-particles and their compaction behaviour--颗粒学报PARTICUOLOGY

Yap, S. F., Adams, M., Seville, J., & Zhang, Z. (2006). Understanding the mechanical properties of single micro-particles and their compaction behaviour. China Particuology, 4(1), 35–40. https://doi.org/10.1016/S1672-2515(07)60231-0

Understanding the mechanical properties of single micro-particles and their compaction behaviour

Siaw Fung Yap ^a, Michael Adams ^a, Jonathan Seville ^a, Zhibing Zhang ^a *

a Centre of Formulation Engineering, Chemical Engineering, School of Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

10.1016/S1672-2515(07)60231-0

Volume 4, Issue 1, February 2006, Pages 35-40

Received 11 October 2005, Accepted 12 November 2005, Available online 14 December 2007.

E-mail: z.zhang@bham.ac.uk

Highlights

Abstract

The compaction of particulate materials to form tablets is increasingly employed as a final dosage form for functional products due to its simplicity and low cost. However, the functionality of some products may be impaired due to the high compression pressures required. The general aim of the current study is to understand the relationship between the mechanical properties of single feed particles (< 100 μm) and their compaction behaviour in order to produce tablets at low compression pressure with acceptable strength. The materials studied were pharmaceutical excipients, comprising three enteric polymer particles and three different powders in the form of agglomerates. The mechanical properties of the individual particles or agglomerates were determined by a micromanipulation technique. The samples were also compacted in cylindrical tableting dies. It was observed that there was a strong correlation between the forces required to cause the fracture of the single particles and those derived from the compaction measurements as determined using an existing analysis.

Graphical abstract

Keywords

compaction; mechanical strength; Eudragit®; rupture stress; micromanipulation; particles

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