Dextran-modified iron oxide nanoparticles--颗粒学报PARTICUOLOGY

Hradil, J., Pisarev, A., Babič, M., & Horák, D. (2007). Dextran-modified iron oxide nanoparticles. China Particuology, 5(1), 162–168. https://doi.org/10.1016/j.cpart.2007.01.003

Dextran-modified iron oxide nanoparticles

Jiří Hradil ^a, Alexander Pisarev ^a, Michal Babič ^a, Daniel Horák ^a *

a Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic Heyrovsky Sq. 2, 162 06 Prague, Czech Republic

10.1016/j.cpart.2007.01.003

Volume 5, Issues 1–2, February–April 2007, Pages 162-168

Received 6 September 2006, Accepted 25 January 2007, Available online 6 June 2007.

E-mail: horak@imc.cas.cz

Highlights

Abstract

Dextran-modified iron oxide nanoparticles were prepared by precipitation of Fe(II) and Fe(III) salts with ammonium hydroxide by two methods. Iron oxide was precipitated either in the presence of dextran solution, or the dextran solution was added after precipitation. In the second method, the iron oxide particle size and size distribution could be controlled depending on the concentration of dextran in the solution. The nanoparticles were characterized by size-exclusion chromatography, transmission electron microscopy and dynamic light scattering. Optimal conditions for preparation of stable iron oxide colloid particles were determined. The dextran/iron oxide ratio 0–0.16 used in precipitation of iron salts can be recommended for synthesis of nanoparticles suitable for biomedical applications, as the colloid does not contain excess dextran and does not coagulate.

Graphical abstract

Keywords

Iron oxide; Nanoparticles; Dextran; Size-exclusion chromatography; Particle size

文章导读