Large scale manufacture of magnetic polymer particles using membranes and microfluidic devices--颗粒学报PARTICUOLOGY

Yuan, Q., & Williams, R. A. (2007). Large scale manufacture of magnetic polymer particles using membranes and microfluidic devices. China Particuology, 5(1), 26–42. https://doi.org/10.1016/j.cpart.2007.02.001

Large scale manufacture of magnetic polymer particles using membranes and microfluidic devices

Qingchun Yuan ^a, Richard A. Williams ^a *

a Institute of Particle Science and Engineering, School of Process Environmental and Materials Engineering, University of Leeds, Clarendon Road, Leeds LS2 9JT, United Kingdom

10.1016/j.cpart.2007.02.001

Volume 5, Issues 1–2, February–April 2007, Pages 26-42

Received 2 November 2006, Accepted 1 February 2007, Available online 6 June 2007.

E-mail: r.a.williams@Leeds.ac.uk

Highlights

Abstract

Magnetic polymer particles have found applications in diverse areas such as biomedical treatments, diagnosis and separation technology. These applications require the particles to have controlled sizes and narrow size distributions to gain better control and reproducibility in use. This paper reviews recent developments in the preparation of magnetic polymer particles at nano- and micro-scales by encapsulating magnetic components with dissolved or in situ formed polymers. Particle manufacture using emulsification and embedment methods produces magnetic polymer particles at micro-scale dimensions. However, the production of particles in this range using conventional emulsification methods affords very limited control over particle sizes and polydispersity. We report on alternative routes using membrane and microfluidics emulsification techniques, which have a capability to produce monodisperse emulsions and polymer microspheres (with coefficients of variation of less than 10%) in the range from submicrometer to a few 100 μm. The performance of these manufacturing methods is assessed with a view to future applications.

Graphical abstract

Keywords

Magnetic polymer particles; Membrane emulsification; Microfluidics emulsification; Large scale manufacture

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