Preparation of ultrafine chitosan particles by reverse microemulsion--颗粒学报PARTICUOLOGY

Liu, G., Shao, L., Ge, F., & Chen, J. (2007). Preparation of ultrafine chitosan particles by reverse microemulsion. China Particuology, 5(6), 384–390. https://doi.org/10.1016/j.cpart.2007.08.002

Preparation of ultrafine chitosan particles by reverse microemulsion

Guogen Liu ^a, Lei Shao ^a *, Fei Ge ^a, Jianfeng Chen^a b

a Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China
b Research Center of Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China

10.1016/j.cpart.2007.08.002

Volume 5, Issue 6, December 2007, Pages 384-390

Received 15 May 2007, Accepted 19 August 2007, Available online 26 November 2007.

E-mail: shaol@mail.buct.edu.cn

Highlights

Abstract

Ultrafine chitosan particles were prepared by reverse microemulsion consisting of water, Triton X-100, octanol and cyclohexane. Two methods of preparing ultrafine chitosan particles were adopted and compared using TEM and IR, and possible mechanisms for the formation of ultrafine chitosan particles were proposed. Experimental results show that the method which combined ionic gelation and cross-linking gave uniformly sized chitosan nanoparticles with an average diameter of 92 nm, while the cross-linking without ionic gelation produced spindly chitosan particles with an average length of 943 nm and width of 188 nm.

Graphical abstract

Keywords

Chitosan; Ultrafine particles; Microemulsion

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