Preparation and functionalization of mesoporous silica spheres as packing materials for HPLC--颗粒学报PARTICUOLOGY

Yang, L., Wang, Y., Luo, G., & Dai, Y. (2008). Preparation and functionalization of mesoporous silica spheres as packing materials for HPLC. Particuology, 6(3), 143–148. https://doi.org/10.1016/j.partic.2008.03.006

Preparation and functionalization of mesoporous silica spheres as packing materials for HPLC

Liming Yang, Yujun Wang, Guangsheng Luo^*, Youyuan Dai

The State Key Laboratory of Chemical Engineering, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China

10.1016/j.partic.2008.03.006

Volume 6, Issue 3, June 2008, Pages 143-148

Received 15 February 2008, Accepted 1 March 2008, Available online 22 May 2008.

E-mail: gsluo@tsinghua.edu.cn

Highlights

Abstract

This paper presents the integrated results of a series of new methods for preparing mesoporous silica spheres as high-performance liquid chromatography (HPLC) packing materials. The separation performance of the mesoporous spheres materials has also been determined. Micrometer-sized silica spheres with uniform spherical morphologies and ordered mesostructures were first successfully synthesized by the method employing a water-soluble polymer-assisted assembly. Then the templates for getting ordered mesoporous materials with high-density silanol groups were removed by using hydrothermal oxidation. Finally the silica spheres were functionalized with C8 alkyl groups by surface modification under hydrothermal conditions. The resultant functionalized silica spheres were demonstrated to be excellent packing materials for HPLC.

Graphical abstract

Keywords

Mesoporous; Silica sphere; Water-soluble polymer; Assembly; HPLC

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