Engineering of drug nanoparticles by HGCP for pharmaceutical applications--颗粒学报PARTICUOLOGY

Hu, T.-T., Wang, J.-X., Shen, Z.-G., & Chen, J.-F. (2008). Engineering of drug nanoparticles by HGCP for pharmaceutical applications. Particuology, 6(4), 239–251. https://doi.org/10.1016/j.partic.2008.04.001

Engineering of drug nanoparticles by HGCP for pharmaceutical applications

Ting-Ting Hu ^a, Jie-Xin Wang ^a, Zhi-Gang Shen ^a, Jian-Feng Chen ^{a b *}

a Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China
b Research Center of Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China

10.1016/j.partic.2008.04.001

Volume 6, Issue 4, August 2008, Pages 239-251

Received 29 December 2007, Accepted 5 April 2008, Available online 15 July 2008.

E-mail: chenjf@mail.buct.edu.cn

Highlights

Abstract

This paper reviews our work on the fundamental principles of high gravity controlled precipitation (HGCP) technology, and its applications in the production of drug nanoparticles, which was carried out in a rotating packed bed (RPB). Several kinds of drug nanoparticles with narrow particle size distributions (PSDs) were successfully prepared via HGCP, including the 300-nm Cefuroxime Axetil (CFA) particles, 200–400-nm cephradine particles, 500-nm salbutamol sulfate (SS) particles (100 nm in width), and 850-nm beclomethasone dipropionate (BDP) particles, etc. Compared to drugs available in the current market, all the drug nanoparticles produced by HGCP exhibited advantages in both formulation and drug delivery, thus improving the bioavailability of drugs. HGCP is essentially a platform technology for the preparation of poorly water-soluble drug nanoparticles for oral and injection delivery, and of inhalable drugs for pulmonary delivery. Consequently, HGCP offers potential applications in the pharmaceutical industry due to its cost-effectiveness, efficient processing and the ease of scaling-up.

Graphical abstract

Keywords

High gravity controlled precipitation; Rotating packed bed; Drug nanoparticle; Poorly water-soluble drug; Inhalable drug

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