Study of cobalt ferrite nanosuspensions for low-frequency ferromagnetic hyperthermia--颗粒学报PARTICUOLOGY

Kashevsky, B. E., Agabekov, V. E., Kashevsky, S. B., Kekalo, K. A., Manina, E. Yu., Prokhorov, I. V., & Ulashchik, V. S. (2008). Study of cobalt ferrite nanosuspensions for low-frequency ferromagnetic hyperthermia. Particuology, 6(5), 322–333. https://doi.org/10.1016/j.partic.2008.07.001

Study of cobalt ferrite nanosuspensions for low-frequency ferromagnetic hyperthermia

Bronislav E. Kashevsky ^a *, Vladimir E. Agabekov ^b, Sergei B. Kashevsky ^a, Katsiaryna A. Kekalo ^b, Elena Yu. Manina ^c, Igor V. Prokhorov^a, Vladimir S. Ulashchik ^c

a A.V. Luikov Heat and Mass Transfer Institute, Belarus Academy of Sciences P. Brovka Str. 15, Minsk 220072, Belarus
b Institute of Chemistry of New Materials, Belarus Academy of Sciences, Skoriny Str. 36, Minsk 220141, Belarus
c Institute of Physiology, Belarus Academy of Sciences, Akademicheskaiy Str. 28, Minsk 220072, Belarus

10.1016/j.partic.2008.07.001

Volume 6, Issue 5, October 2008, Pages 322-333

Received 6 February 2008, Accepted 7 July 2008, Available online 29 August 2008.

E-mail: bekas@itmo.by

Highlights

Abstract

High-coercive cobalt ferrite nanoparticles were synthesized and studied for magnetic hyperthermia by direct injection of their suspension into a tumor and application of a strong audio-frequency magnetic field for heating. Physical (dynamic magnetic hysteresis and heat generation in both liquid and solid dispersions), biological (toxicity and penetration of particles in therapeutic quantities into mouse tumor tissue) as well as other properties of the particles were studied. A model was developed to describe the magnetodynamics in suspensions of magnetic nanoclusters with an account for both Brownian and regular rotations, to provide understanding of observed phenomena. The experimental and theoretical techniques developed have formed a basis for controllable synthesis of the magnetic nanoparticles for low-frequency heat generation in medical and other applications.

Graphical abstract

Keywords

Cobalt ferrite nanoparticles; Magnetic suspensions; Dynamic magnetic hysteresis; Medical hyperthermia

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