DEM simulations of die filling during pharmaceutical tabletting--颗粒学报PARTICUOLOGY

Wu, C.-Y. (2008). DEM simulations of die filling during pharmaceutical tabletting. Particuology, 6(6), 412–418. https://doi.org/10.1016/j.partic.2008.07.008

DEM simulations of die filling during pharmaceutical tabletting

Chuan-Yu Wu^*

School of Chemical Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK

10.1016/j.partic.2008.07.008

Volume 6, Issue 6, December 2008, Pages 412-418

Received 24 February 2008, Accepted 15 July 2008, Available online 11 November 2008.

E-mail: C.Y.Wu@bham.ac.uk

Highlights

Abstract

The flow behaviour of powders from a stationary shoe into a moving die, which mimics the die filling process in a rotary tablet press, was analysed using a discrete element method (DEM), in which 2D irregular shaped particles were considered. The influence of the particle shape, size and size distribution, the number of particles used in the simulation, the initial height of powder bed in the shoe, and the filling speed on the average mass flow rate and the critical filling speed (the highest speed at which the die can be completely filled) were explored. It has been found that a maximum flow rate is obtained at the critical filling speed for all systems investigated and poly-disperse systems have higher mass flow rates and higher critical filling speeds than mono-disperse systems. In addition, the powder with particles which can tessellate generally has a lower filling rate and a lower critical filling speed.

Graphical abstract

Keywords

DEM; Die filling; Tabletting; Powder compaction; Mass flow rate; Critical filling speed

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