Physical characterization of meloxicam-β-cyclodextrin inclusion complex pellets prepared by a fluid-bed coating method--颗粒学报PARTICUOLOGY

Lu, Y., Zhang, X., Lai, J., Yin, Z., & Wu, W. (2009). Physical characterization of meloxicam-β-cyclodextrin inclusion complex pellets prepared by a fluid-bed coating method. Particuology, 7(1), 1–8. https://doi.org/10.1016/j.partic.2008.11.004

Physical characterization of meloxicam-β-cyclodextrin inclusion complex pellets prepared by a fluid-bed coating method

Yi Lu ^a, Xingwang Zhang ^a, Jie Lai ^b, Zongning Yin ^b *, Wei Wu ^a *

a School of Pharmacy, Fudan University, Shanghai, China
b West China School of Pharmacy, Sichuan University, Chengdu, China

10.1016/j.partic.2008.11.004

Volume 7, Issue 1, 18 February 2009, Pages 1-8

Received 13 August 2008, Accepted 10 November 2008, Available online 13 January 2009.

E-mail: yzn@scu.edu.cn; wuwei@shmu.edu.cn

Highlights

Abstract

Meloxicam-β-cyclodextrin (ME-β-CD) inclusion complex was prepared by a fluid-bed coating technique upon solvent removal and simultaneous depositing onto the surface of nonpareil pellets and using PVP K30 as a binding agent to facilitate good coating. The resultant pellets were spherical and intact in shape with good flowability and friability. SEM analysis showed that the pellets were smooth and had a tightly coated inclusion complex layer. In vitro dissolution of the inclusion complex pellets in pH 7.4 phosphate buffer was dramatically enhanced at an ME/CD ratio of 1/1. DSC and powder X-ray diffractometry proved the absence of crystallinity in the ME/CD inclusion complexes. Moreover, Fourier transform-infrared spectrometry together with Raman spectrometry indicated that the thiazole ring of ME was possibly included in the cavity of β-CD.

Graphical abstract

Keywords

Meloxicam; Inclusion complex; β-Cyclodextrin; Fluid-bed; Pellets; Dissolution; Characterization

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