Flow behavior and deposition study of pollen-shape carrier particles in an idealized inhalation path model--颗粒学报PARTICUOLOGY

Hassan, M. S., & Lau, R. (2010). Flow behavior and deposition study of pollen-shape carrier particles in an idealized inhalation path model. Particuology, 8(1), 51–59. https://doi.org/10.1016/j.partic.2009.05.004

Flow behavior and deposition study of pollen-shape carrier particles in an idealized inhalation path model

Meer Saiful Hassan, Raymond Lau^*

School of Chemical and Biomedical Engineering (SCBE), Nanyang Technological University (NTU), 62 Nanyang Drive, Singapore 637459, Singapore

10.1016/j.partic.2009.05.004

Volume 8, Issue 1, February 2010, Pages 51-59

Received 22 December 2008, Accepted 30 May 2009, Available online 3 October 2009.

E-mail: wmlau@ntu.edu.sg

Highlights

Abstract

Pollen-shape (spiked sphere) hydroxyapatite (HA) particles for drug carrier application are studied. The particle shape and size effect on flow characteristics and deposition are assessed. The pollen-shape HA particles are synthesized to have comparable size as typical carrier particles with mean diameter of 30–50 μm and effective density less than 0.3 g/cm³. The flow behaviors of HA and commonly used lactose (LA) carrier particles are characterized by the Carr's compressibility index (CI). The HA particles have lower CI than the LA particles for the same size range. The flow fields of HA and LA carrier particles are measured in an idealized inhalation path model using particle image velocimetry (PIV) technique. The particle streamlines indicate that a large portion of particles may deposit at the bending section due to inertial impaction and gravitational deposition. The flow field result shows that HA particles give smaller separation regions than the LA particles for the same size range. The pollen-shape HA particles are found to be able to follow the gas flow in the model and minimize undesired deposition. Deposition result confirms the bending section to have the most deposition. Deposition is found to be a function of particle properties. An empirical correlation is derived for the deposition efficiency of the pollen-shape particles as a function of particles Stokes number.

Graphical abstract

Keywords

Aerosol; Fluid mechanics; Multiphase flow; Particle; Powder technology; Pulmonary drug delivery

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