Preparation of mesoporous silica microspheres with multi-hollow cores and their application in sustained drug release--颗粒学报PARTICUOLOGY

Zhang, C., Hou, T., Chen, J., & Wen, L. (2010). Preparation of mesoporous silica microspheres with multi-hollow cores and their application in sustained drug release. Particuology, 8(5), 447-452. https://doi.org/10.1016/j.partic.2010.05.012

Preparation of mesoporous silica microspheres with multi-hollow cores and their application in sustained drug release

Chen Zhang ^a, Tian Hou ^a, Jianfeng Chen ^{a b}, Lixiong Wen ^a *

a Key Lab for Nanomaterials, Ministry of Education, Beijing University of Chemical Technology, Beijing 100029, China
b Research Center of the Ministry of Education for High Gravity Engineering & Technology, Beijing University of Chemical Technology, Beijing 100029, China

10.1016/j.partic.2010.05.012

Volume 8, Issue 5, October 2010, Pages 447-452

Received 4 March 2010, Revised 28 April 2010, Accepted 21 May 2010, Available online 22 September 2010.

E-mail: wenlx@mail.buct.edu.cn

Highlights

Abstract

Mesoporous silica microspheres with multi-hollow cores (MSMMCs) were prepared by an O₁/W/O₂ double emulsion technique. When tetraethyl orthosilicate (TEOS) was hydrolyzed in the O₁/W/O₂ double emulsion with P123 (a triblock copolymer with a formula of HO(CH₂CH₂O)₂₀(CH₂CH(CH₃)O)₇₀(CH₂CH₂O)₂₀H) dissolved in the aqueous phase, the internal oil droplets would serve as templates for the empty hollow cores, P123 function as templates for the mesopores in the shell, and the aqueous phase act as space-limiting micro-reactors for the hydrolysis process, thus forming MSMMCs with controllable size and hollow cores. After further modification by a high-temperature aging process, the prepared MSMMCs had a diameter of 2–10 μm, with macro-multi-hollow cores with a size of 100–1000 nm, mesopores in the shell with a size of 3.8–4.4 nm, and a surface area of 383–735 m²/g. In addition, MSMMCs were used as carriers to load avermectin through an immersing and evaporating process, and the loaded avermectin showed a well sustained release behavior from the MSMMCs matrix. This study demonstrated a promising and simple method for preparing silica micro-particles with porous multi-hollow core structure for sustained release applications.

Graphical abstract

Keywords

Silica; Preparation; Hollow structure; Sustained release

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