Controllable precipitation of naproxen micro-particles with different morphologies--颗粒学报PARTICUOLOGY

Cheng, P., Jin, K., Cheng, J., Yang, F., Shen, Z., Chen, J., & Wen, L. (2012). Controllable precipitation of naproxen micro-particles with different morphologies. Particuology, 10(5), 634–643. https://doi.org/10.1016/j.partic.2012.04.004

Controllable precipitation of naproxen micro-particles with different morphologies

Peng Cheng ^a, Kangkang Jin ^a, Jing Cheng ^a, Fang Yang ^b, Zhigang Shen ^a, Jianfeng Chen ^{a b}, Lixiong Wen ^a *

a State Key Laboratory of Organic-Inorganic Composites, Beijing University of Chemical Technology, Beijing 100029, China
b Research Center of the Ministry of Education for High Gravity Engineering & Technology, Beijing University of Chemical Technology, Beijing 100029, China

10.1016/j.partic.2012.04.004

Volume 10, Issue 5, October 2012, Pages 634-643

Received 18 April 2011, Revised 19 April 2012, Accepted 26 April 2012, Available online 5 July 2012.

E-mail: wenlx@mail.buct.edu.cn

Highlights

► Naproxen micro-particles with controllable morphologies were prepared with the help of surfactants.

► Different shapes of naproxen particles were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like.

► Size and morphology of precipitated naproxen particles were affected by type and concentration of the surfactant used, as well as precipitation conditions.

Abstract

A simple precipitation method was proposed to prepare naproxen micro-particles with different controllable morphologies, using capillary video microscopy to study the precipitation process. Different particle shapes were obtained including spherical, platelet-like, stick-like, needle-like, and butterfly-like, all in the micro-size range. It was found that the sizes and morphologies of the formed naproxen particles were sensitive to the nature and concentration of the added surfactant, and depended significantly on processing conditions such as temperature, stirring speed, and initial drug concentration. In addition, precipitation with different surfactant types and concentrations would not affect the crystal microstructure of the formed naproxen particles.

Graphical abstract

Keywords

Precipitation; Crystal growth; Naproxen; Surfactants

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