Particle size and packing characterization by diffuse light transmission--颗粒学报PARTICUOLOGY

Ehlers, H., Heinämäki, J., & Yliruusi, J. (2012). Particle size and packing characterization by diffuse light transmission. Particuology, 10(5), 619–627. https://doi.org/10.1016/j.partic.2011.12.005

Particle size and packing characterization by diffuse light transmission

Henrik Ehlers ^{a b *}, Jyrki Heinämäki ^{a c}, Jouko Yliruusi ^a

a Division of Pharmaceutical Technology, Faculty of Pharmacy, P.O. Box 56 (Viikinkaari 5 E), FI-00014 University of Helsinki, Finland
b Pharmaceutical Sciences Laboratory, Department of Biosciences, Åbo Akademi University, BioCity, Artillerigatan 6, 20520 Turku, Finland
c Department of Pharmacy, Faculty of Medicine, University of Tartu, Nooruse 1, 50411 Tartu, Estonia

10.1016/j.partic.2011.12.005

Volume 10, Issue 5, October 2012, Pages 619-627

Received 17 June 2011, Revised 30 September 2011, Accepted 12 December 2011, Available online 21 April 2012.

E-mail: henrik.ehlers@helsinki.fi

Highlights

► Particle size, packing density and blend composition of glass ballotini, microcrystalline cellulose pellets and theophylline granules were studied by diffuse light transmission.

► Light transmission was found to decrease with decreasing particle size and with increasing packing density. The effect of packing density was significant.

► The method proposed can readily provide information on change in the granular sample.

Abstract

Particle size, packing density and blend composition of glass ballotini, microcrystalline cellulose pellets and theophylline granules were studied by diffuse light transmission. Diffuse visible light was directed to the sample and the intensity of the light transmitted to the opposite side of the sample was measured through a diffusing lens using a phototransistor. Light transmission was found to decrease with decreasing particle size and with increasing packing density. There was a correlation, though somewhat irregular, between light transmission and particle size for glass ballotini and microcrystalline cellulose pellets, and a strong near-linear correlation between light transmission and particle size for theophylline granules. The effect of packing density on light transmission was significant. Differentiating the composition of binary blends of microcrystalline cellulose pellets and glass ballotini and blends of theophylline granules was found possible on the basis of light transmission. The method proposed showed potential as a rapid, simple and inexpensive analytical tool for basic process diagnostics.

Graphical abstract

Keywords

Light transmission; Particle size; Packing density; Convection; Segregation

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