Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction--颗粒学报PARTICUOLOGY

Krok, A., Peciar, M., & Fekete, R. (2014). Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction. Particuology, 16, 116–131. https://doi.org/10.1016/j.partic.2013.12.003

Numerical investigation into the influence of the punch shape on the mechanical behavior of pharmaceutical powders during compaction

Alexander Krok^*, Marián Peciar, Roman Fekete

Slovak University of Technology in Bratislava, Faculty of Mechanical Engineering, Bratislava, Slovak Republic

10.1016/j.partic.2013.12.003

Volume 16, October 2014, Pages 116-131

Received 9 September 2013, Revised 21 November 2013, Accepted 3 December 2013, Available online 28 February 2014.

E-mail: alexander.krok@stuba.sk

Highlights

• The calibration procedure of Drucker–Prager cap model was discussed for powder compaction.

• Mechanical behavior of powder during compaction was modeled using FEM together with DPC model.

• Influences of punch shape and wall friction on powder compaction were investigated.

Abstract

During the production of pharmaceutical tablets using powder compaction, certain common problems can occur, such as sticking, tearing, cutting, and lamination. In the past, the compressibility of the powder was calculated only along the axis of the device; consequently, critical areas of the material throughout the volume could not be identified. Therefore, finite element method (FEM) can be used to predict these defects in conjunction with the use of an appropriate constitutive model. This article summarizes the current research in the field of powder compaction, describes the Drucker–Prager Cap model calibration procedure and its implementation in FEM, and also examines the mechanical behavior of powder during compaction. In addition, the mechanical behavior of pharmaceutical powders in relation to changes in friction at the wall of the system is examined, and the dependence of lubrication effect on the geometry of the compaction space is also investigated. The influence of friction on the compaction process for the flat-face, flat-face radius edge, and standard convex tablets is examined while highlighting how the effects of friction change depending on the shape of these tablets.

Graphical abstract

Keywords

Powder; Die compaction; FEM

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