Preparation of high-purity monodisperse silica microspheres by the sol–gel method coupled with polymerization-induced colloid aggregation--颗粒学报PARTICUOLOGY

Zhao, B., Zhang, Y., Tang, T., Wang, F., Li, T., & Lu, Q. (2015). Preparation of high-purity monodisperse silica microspheres by the sol–gel method coupled with polymerization-induced colloid aggregation. Particuology, 22, 177-184. https://doi.org/10.1016/j.partic.2014.08.005

Preparation of high-purity monodisperse silica microspheres by the sol–gel method coupled with polymerization-induced colloid aggregation

Beibei Zhao ^a *, Yan Zhang ^b, Tao Tang ^{b c}, Fengyun Wang ^b, Tong Li ^c, Qiyu Lu ^a

a College of Food Science and Technology, Henan University of Technology, Zhengzhou 450001, China
b Chemical Engineering Institute, Nanjing University of Science and Technology, Nanjing 210094, China
c Dalian Elite Analytical Instruments Co., Ltd., Dalian 116023, China

10.1016/j.partic.2014.08.005

Volume 22, October 2015, Pages 177-184

Received 5 June 2014, Revised 30 July 2014, Accepted 9 August 2014, Available online 26 December 2014, Version of Record 4 August 2015.

E-mail: gentlebeibei@163.com

Highlights

• Mesoporous silica particles (MSPs) were synthesized by sol–gel method coupled with PICA.

• The prepared MSPs were spherical, monodisperse, with low metal content.

• Using the MSPs as stationary phase could improve peak tailing in HPLC.

• Particle size and pore structure could be controlled by adjusting preparation parameters.

Abstract

Ultra-pure mesoporous silica microspheres with good monodispersity were synthesized in two steps: nanometer-sized silica sol was produced by the sol–gel process, then micrometer-sized silica microspheres were synthesized by polymerization-induced colloid aggregation of the silica sol. The total metal content of the microspheres was extremely low, which eliminated the tailing of chromatographic peaks by chelating reagents. The pore structure of the silica microspheres could be controlled by altering the sol–gel conditions. The silica microsphere particle size could be adjusted by using different polymerization-induced colloid aggregation conditions.

Graphical abstract

Keywords

Sol–gel; Polymerization-induced colloid aggregation; Silica; High purity; Monodisperse

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