On the spray drying of uniform functional microparticles--颗粒学报PARTICUOLOGY

Liu, W., Chen, X. D., & Selomulya, C. (2015). On the spray drying of uniform functional microparticles. Particuology, 22, 1-12. https://doi.org/10.1016/j.partic.2015.04.001

On the spray drying of uniform functional microparticles

W. Liu ^{a b}, X.D. Chen^c, C. Selomulya ^a *

a Department of Chemical Engineering, Monash University, 18 Alliance Lane, Clayton 3800, VIC, Australia
b Department of Pharmaceutics, School of Pharmaceutical Sciences, Central South University, Changsha 410013, China
c School of Chemical and Environmental Engineering, Soochow University, Suzhou Industrial Park, Suzhou 215006, China

10.1016/j.partic.2015.04.001

Volume 22, October 2015, Pages 1-12

Received 21 April 2015, Accepted 23 April 2015, Available online 6 June 2015, Version of Record 4 August 2015.

E-mail: cordelia.selomulya@monash.edu

Highlights

• Microfluidic spray drying can be used to produce uniform microparticles with tailored properties.

• Microparticle synthesis was exemplified with focus on microencapsulation and controlled release.

• Effects of formulation and drying conditions on functional particle properties were emphasised.

Abstract

Spray drying is a typical method to produce particles in dry powder forms at industrial scale. Most spray-dried products often show a wide range of particle properties even within the same batch. At Monash University, we utilise a microfluidic spray drying approach to generate uniform microparticles with tightly controlled characteristics and sizes in a scalable, almost waste-free process. The technique is useful to correlate the effects of formulation and spray drying conditions on the properties of spray-dried particles, and can be used to test new formulations for targeted applications such as encapsulation and release of active ingredients. The synthesis route can be applied to other self-assembling systems, including mesoporous, crystalline, and hierarchically structured microparticles. As spray drying is commonly used in commercial scales, the understanding of how functional particles are formed in relation to formulations and process conditions could assist in developing a cost effective, energy and material-efficient route to produce powders with better properties and ease of handling for more advanced applications such as selective adsorption and bio-separation.

Graphical abstract

Keywords

Microfluidic spray drying; Uniform microparticles; Encapsulation; Controlled release

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