Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems--颗粒学报PARTICUOLOGY

Leong, J.-Y., Lam, W.-H., Ho, K.-W., Voo, W.-P., Lee, M. F.-X., Lim, H.-P., . . . Chan, E.-S. (2016). Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems. Particuology, 24, 44-60. https://doi.org/10.1016/j.partic.2015.09.004

Advances in fabricating spherical alginate hydrogels with controlled particle designs by ionotropic gelation as encapsulation systems

Jun-Yee Leong ^a, Weng-Hoong Lam ^a, Kiang-Wei Ho ^a, Wan-Ping Voo ^a, Micky Fu-Xiang Lee ^a, Hui-Peng Lim ^a, Swee-Lu Lim ^a, Beng-Ti Tey ^{a b}, Denis Poncelet ^c, Eng-Seng Chan ^{a b *}

a Chemical Engineering Discipline, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor 46150, Malaysia
b Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway, Selangor 46150, Malaysia
c Oniris, UMR CNRS 6144 GEPEA, rue de la Géraudière, BP82225, Nantes 44322, France

10.1016/j.partic.2015.09.004

Volume 24, February 2016, Pages 44-60

Received 25 March 2015, Revised 23 August 2015, Accepted 6 September 2015, Available online 3 December 2015, Version of Record 21 January 2016.

E-mail: chan.eng.seng@monash.edu

Highlights

• Alginate hydrogel has emerged as a popular encapsulation system.

• Various alginate particle designs were discussed.

• Methods used to disperse alginate droplets were systematically categorized.

• Five major types of gelation mechanisms were overviewed.

• Considerations in designing alginate hydrogels were discussed.

Abstract

Alginate is a biopolymer that has exceptional gelling properties, which allow easy gel formation under safe and mild conditions. Consequently, it is often used to encapsulate a variety of cargos, such as cells, enzymes, and lipids, and is typically employed as a model to study hydrogel-based encapsulation systems. Since the first use of alginate in the encapsulation field in the 1970s, many methods have been developed to produce alginate hydrogel particles of different sizes, structures, and morphologies. This review provides an overview of the current progress in the fabrication of alginate hydrogels with various particle designs, including a discussion of dispersion techniques to pre-template alginate particles, gelation mechanisms, considerations in selecting suitable fabrication methods, and future directions.

Graphical abstract

Keywords

Alginate; Ionotropic gelation; Immobilization; Encapsulation; Hydrogel

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