Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model--颗粒学报PARTICUOLOGY

Chen, X., Zhong, W., Tom, J., Kleinstreuer, C., Feng, Y., & He, X. (2016). Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model. Particuology, 28, 102-113. https://doi.org/10.1016/j.partic.2016.02.002

Experimental-computational study of fibrous particle transport and deposition in a bifurcating lung model

Xiaole Chen ^a, Wenqi Zhong ^a *, Josin Tom ^b, Clement Kleinstreuer ^{b c}, Yu Feng ^d, Xiaopu He ^e

a Key Laboratory of Energy Thermal Conversion and Control of the Ministry of Education, School of Energy and Environment, Southeast University, Nanjing 210096, China
b Department of Mechanical and Aerospace Engineering, North Carolina State University, Raleigh, NC 27695, USA
c Department of Biomedical Engineering, North Carolina State University, Raleigh, NC 27695, USA
d School of Chemical Engineering, Oklahoma State University, Stillwater, OK 74078, USA e First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

10.1016/j.partic.2016.02.002

Volume 28, October 2016, Pages 102-113

Received 3 August 2015, Revised 26 December 2015, Accepted 11 February 2016, Available online 8 June 2016, Version of Record 4 August 2016.

E-mail: wqzhong@seu.edu.cn

Highlights

• Fiber deposition experiments were carried out in a single-bifurcation airway model.

• Deposition fractions and orientation under effects of impaction and sedimentation were recorded.

• Deposition characteristics in lower airway were estimated by matching results for St and γ.

• Orientations of deposited fibers were obtained by image processing method.

• Gravitational effect on the deposition cannot be neglected for 0.0228 < γ < 0.247.

Abstract

Experiments carried out using a lung model with a single horizontal bifurcation under different steady inhalation conditions explored the orientation of depositing carbon fibers, and particle deposition fractions. The orientations of deposited fibers were obtained from micrographs. Specifically, the effects of the sedimentation parameter (γ), fiber length, and flow rate on orientations were analyzed. Our results indicate that gravitational effect on deposition cannot be neglected for 0.0228 < γ < 0.247. The absolute orientation angle of depositing fibers decreased linearly with increasing γ for values 0.0228 < γ < 0.15. Correspondence between Stokes numbers and γ suggests these characteristics can be used to estimate fiber deposition in the lower airways. Computer simulations with sphere-equivalent diameter models for the fibers explored deposition efficiency vs. Stokes number. Using the volume-equivalent diameter model, our experimental data for the horizontal bifurcation were replicated. Results for particle deposition using a lung model with a vertical bifurcation indicate that body position also affects deposition.

Graphical abstract

Keywords

Lung aerosol dynamics; Image-processing method; Fiber deposition data; Computer simulations; Deposited fiber orientations

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