Red-blood-cell-shaped chitosan microparticles prepared by electrospraying--颗粒学报PARTICUOLOGY

Ju, X., Wang, X., Liu, Z., Xie, R., Wang, W., & Chu, L. (2017). Red-blood-cell-shaped chitosan microparticles prepared by electrospraying. Particuology, 30, 151-157. https://doi.org/10.1016/j.partic.2016.05.011

Red-blood-cell-shaped chitosan microparticles prepared by electrospraying

Xiaojie Ju ^{a b *}, Xiaoxue Wang ^a, Zhuang Liu ^a, Rui Xie ^{a b}, Wei Wang ^{a b}, Liangyin Chu ^{a b}

a School of Chemical Engineering, Sichuan University, Chengdu 610065, China
b State Key Laboratory of Polymer Materials Engineering, and Collaborative Innovation Center for Biomaterials Science and Technology, Sichuan University, Chengdu 610065, China

10.1016/j.partic.2016.05.011

Volume 30, February 2017, Pages 151-157

Received 23 February 2016, Revised 1 May 2016, Accepted 28 May 2016, Available online 25 September 2016, Version of Record 27 January 2017.

E-mail: juxiaojie@scu.edu.cn

Highlights

• Red-blood-cell-shaped (RBC) chitosan microparticles were fabricated by electrospraying.

• A novel strategy was developed to control solvent diffusion via solvent evaporation.

• Control of solvent diffusion was crucial to form RBC-shaped chitosan microparticles.

Abstract

Red-blood-cell-shaped chitosan microparticles with acid-triggered dissolution and auto-fluorescence were successfully fabricated by a simple strategy combining electrospraying with a solvent diffusion process controlled by solvent evaporation. The sizes of the prepared chitosan microparticles were relatively uniform. Control of the solvent diffusion process was crucial for the formation of microparticles with concave morphology. A chitosan aqueous solution containing 20 vol% ethanol as the evaporable solvent and 30 vol% dimethyl sulfoxide as the diffusible solvent was optimal for preparation of chitosan microparticles with the desired red-blood-cell-like size and shape. These chitosan microparticles will be highly attractive for many biological and biomedical applications.

Graphical abstract

Keywords

Chitosan microparticle; Red blood cell; Electrospraying; Solvent evaporation; Solvent diffusion

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