Magnetic nanoparticles for environmental and biomedical applications: A review--颗粒学报PARTICUOLOGY

Mohammed, L., Gomaa, H. G., Ragab, D., & Zhu, J. (2017). Magnetic nanoparticles for environmental and biomedical applications: A review. Particuology, 30, 1-14. https://doi.org/10.1016/j.partic.2016.06.001

Magnetic nanoparticles for environmental and biomedical applications: A review

Leena Mohammed, Hassan G. Gomaa ^*, Doaa Ragab, Jesse Zhu

Chemical and Biochemical Engineering Department, Western University, London, Ontario N6A 5B9, Canada

10.1016/j.partic.2016.06.001

Volume 30, February 2017, Pages 1-14

Received 13 March 2016, Revised 30 May 2016, Accepted 1 June 2016, Available online 10 August 2016, Version of Record 27 January 2017.

E-mail: Hgomaa@uwo.ca

Highlights

• Environmental and biomedical potential of magnetic nanoparticles (MNPs) is discussed.

• MNPs can be used directly for pollutant removal from contaminated water resources.

• MNPs can be incorporated onto membrane material to enhance contaminant removal.

• MNPs' unique properties allow application in targeted drug delivery and imaging.

• Special features of superparamagnetic nanoparticles (SPIONs) are discussed.

Abstract

Engineered magnetic nanoparticles (MNPs) hold great potential in environmental, biomedical, and clinical applications owing to their many unique properties. This contribution provides an overview of iron oxide MNPs used in environmental, biomedical, and clinical fields. The first part discusses the use of MNPs for environmental purposes, such as contaminant removal, remediation, and water treatment, with a focus on the use of zero-valent iron, magnetite (Fe₃O₄), and maghemite (γ-Fe₂O₃) nanoparticles, either alone or incorporated onto membrane materials. The second part of this review elaborates on the use of MNPs in the biomedical and clinical fields with particular attention to the application of superparamagnetic iron oxide nanoparticles (SPIONs), which have gained research focus recently owing to their many desirable features such as biocompatibility, biodegradability, ease of synthesis and absence of hysteresis. The properties of MNPs and their ability to work at both cellular and molecular levels have allowed their application in vitro and in vivo including drug delivery, hyperthermia treatment, radio-therapeutics, gene delivery, and biotherapeutics. Physiochemical properties such as size, shape, and surface and magnetic properties as well as agglomeration of MNPs and methods to enhance their stability are also discussed.

Graphical abstract

Keywords

Magnetic nanoparticle; Water treatment; SPION; Biomedical application

文章导读