An update on electrostatic powder coating for pharmaceuticals--颗粒学报PARTICUOLOGY

Yang, Q., Ma, Y., Zhu, J., Chow, K., & Shi, K. (2017). An update on electrostatic powder coating for pharmaceuticals. Particuology, 31, 1-7. https://doi.org/10.1016/j.partic.2016.10.001

An update on electrostatic powder coating for pharmaceuticals

Qingliang Yang ^{a c}, Yingliang Ma ^{a b}, Jesse Zhu ^a^c*, Kwok Chow ^b, Kaiqi Shi ^c

a Particle Technology Research Centre, Department of Chemical and Biochemical Engineering, University of Western Ontario, London, Ontario N6A 5B9, Canada
b Powder Pharma Coatings, Mississauga, Ontario L5R 2Y9, Canada
c Ningbo Weston Powder Pharma Coatings Co. Ltd., Ningbo, Zhejiang 315 042, China

10.1016/j.partic.2016.10.001

Volume 31, April 2017, Pages 1-7

Received 21 June 2016, Revised 2 October 2016, Accepted 12 October 2016, Available online 11 January 2017, Version of Record 9 March 2017.

E-mail: jzhu@uwo.ca

Highlights

• A brief introduction of electrostatic dry powder coatings was given.

• Principles, apparatus, and formulations of the "ExsicCoat" technology were summarized.

• Film formation could be influenced by the curing temperature, time, and particle size.

• Future work includes moisture sensitive drugs, coating materials with high T_g.

Abstract

Derived from dry powder coating of metals, electrostatic powder coating for pharmaceuticals is a technology for coating drug solid dosage forms. In this technology, coating powders, containing coating polymers, pigments, and other excipients, are directly sprayed onto the surface of the solid dosage forms through an electrostatic gun without using any organic solvent or water. The deposited coating powders are further cured to form a coating film. Electrostatic powder coating technology has many advantages compared to other pharmaceutical coating methods. It can eliminate the limitations caused by the organic solvent in solvent coating such as environmental issues and health problems. And electrostatic powder coating technology also surpasses aqueous coating due to its shorter processing time and less energy consumption, leading to a lower overall cost. Furthermore, the utilization of electrical attraction can promote the movement of coating powders towards the substrate, leading to an enhanced coating powder adhesion and coating efficiency, which make it more promising compared to other dry coating technologies. The objective of this review is to summarize the coating principles, apparatus, and formulations of different electrostatic powder coating technologies, giving their advantages and limitations and also analyzing the future application in the industry for each technology.

Graphical abstract

Keywords

Electrostatic powder coating; Solid dosage forms; Plasticizers; Powder adhesion; Film formation; Curing

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