Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery--颗粒学报PARTICUOLOGY

Freitas, E. D., Vidart, J. M. M., Silva, E. A., da Silva, M. G. C., & Vieira, M. G. A. (2018). Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery. Particuology, 41, 65-73. https://doi.org/10.1016/j.partic.2017.12.011

Development of mucoadhesive sericin/alginate particles loaded with ibuprofen for sustained drug delivery

Emanuelle D. Freitas ^a, Jacyara M.M. Vidart ^a, Edson A. Silva ^b, Meuris G.C. da Silva ^a, Melissa G.A. Vieira ^a *

a Department of Processes and Products Design, School of Chemical Engineering, University of Campinas–UNICAMP, Albert Einstein Avenue, 500, 13083-852, Campinas, SP, Brazil
b School of Chemical Engineering, State University of West Paraná–UNIOESTE, Faculdade Street, 645, 85903-000, Toledo, PR, Brazil

10.1016/j.partic.2017.12.011

Volume 41, December 2018, Pages 65-73

Received 16 October 2017, Revised 1 December 2017, Accepted 13 December 2017, Available online 19 May 2018, Version of Record 1 November 2018.

E-mail: melissagav@feq.unicamp.br

Highlights

• Sericin/alginate blend was used as polymeric matrix for ibuprofen incorporation.

• Incorporation efficiency was improved by the addition of sericin as well as polyethylene glycol.

• Sustained drug release was reached by formulation with greater amounts of alginate.

• Sericin could contribute to improve homogeneity of particles size distribution.

Abstract

A sericin/alginate blend was successfully applied as a matrix for incorporation of ibuprofen. This provided a sustained release formulation, which could improve the therapeutic efficacy of ibuprofen and patient adherence to treatment. Sericin increased the proportion of drug incorporated into the particles (i.e., the drug incorporation efficiency), with incorporation rates between 73.01% ± 1.70% and 94.15% ± 4.21%. Alginate affected the drug release, and the particles with the maximum alginate mass fraction tested (2.8%) showed sustained release through a dissolution mechanism, reaching equilibrium after about 1400 min. Analysis of the incorporation efficiency and the drug release time showed the best results were for formulations with a high alginate content. Scanning electron microscopy, Fourier transform infrared spectroscopy, and X-ray diffraction analysis were used for particle characterization to study the incorporation of ibuprofen. The particle size range was 0.80 ± 0.13 to 1.08 ± 0.11 mm. The size distributions of sericin-containing particles showed a good fit with the Gaussian model.

Graphical abstract

Keywords

Sericin; Alginate; Ibuprofen; Sustained drug release

文章导读