Pharmaceutical applications of spouted beds: A review on solid dosage forms--颗粒学报PARTICUOLOGY

de Freitas, L. A. P. (2019). Pharmaceutical applications of spouted beds: A review on solid dosage forms. Particuology, 42, 126-136. https://doi.org/10.1016/j.partic.2018.05.002

Pharmaceutical applications of spouted beds: A review on solid dosage forms

Luís Alexandre Pedro de Freitas ^*

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, University of São Paulo, Via do Café s/n, Campus USP, Ribeirão Preto, 14040-903, São Paulo, BrazilLuís Alexandre Pedro de Freitas

10.1016/j.partic.2018.05.002

Volume 42, February 2019, Pages 126-136

Received 22 December 2017, Revised 3 May 2018, Accepted 21 May 2018, Available online 4 October 2018, Version of Record 21 January 2019.

E-mail: lapdfrei@usp.br

Highlights

• Review on spouted bed applications to drying and coating of pharmaceutical solid dosage forms.

• Review on new application of β-cyclodextrin inclusion complexes in spouted beds.

• Critical review on spouted bed dryer effect on bioactives properties.

• Review on spouted bed effect on pharmacotechnical properties of powders.

Abstract

Spouted beds (SBs) have a long history of successful applications for preparation of solid dosage forms of pharmaceuticals. The well-known versatility of SBs, provided by different design and operational factors, and their efficient mixing of solids allow for engineering of technological characteristics of pharmaceutical solid forms. Particle properties like morphology, size, porosity, flowability, and dissolution rate can be improved by managing geometric and operational conditions for spouting. Drying is probably the most disseminated operation for pharmaceutical processing in SBs, and many studies have investigated drying of medicinal plant extracts such as achiote (Bixa orellana sp.), guarana (Paullinia cupana sp.), passion flower (Passiflora alata D.), and rosemary (Rosmarinus officinalis L.) with excellent pharmacotechnical and stability results. Another important application is coating of tablets and gelatin capsules, and previous studies have shown that SBs and spout–fluid beds may be advantageous over traditional pan coating, especially for polymeric film coating. Recently, an alternative process for improving drug bioavailability has involved preparation of β-cyclodextrin inclusion complexes in SBs. The first study to propose SBs for this pharmaceutical application explored the advantage of obtaining solid forms of inclusion complexes in just one step, and obtained expressive increases in drug solubility. The technique has been applied in subsequent studies on inclusion complexes of the medication carvedilol and uxi (Endopleura uchi L.) extracts.

Graphical abstract

Keywords

Coating; Drying; Granulation; Inclusion; Microencapsulation

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