Mechanistic analysis of solid–liquid flow during injection--颗粒学报PARTICUOLOGY

Cai, J., Wu, C.-Y., Guo, Y., Yang, J., & Zhao, X. (2019). Mechanistic analysis of solid–liquid flow during injection. Particuology, 44, 136-145. https://doi.org/10.1016/j.partic.2018.05.008

Mechanistic analysis of solid–liquid flow during injection

Jie Cai ^{a b *}, Chuan-Yu Wu ^a *, Yu Guo ^c, Jiecheng Yang ^a, Xiaobao Zhao ^b

a Department of Chemical and Process Engineering, University of Surrey, Guildford GU2 7XH, UK
b School of Energy and Mechanical Engineering, Nanjing Normal University, Nanjing 210042, China
c School of Aeronautics and Astronautics, Zhejiang University, Hangzhou 310058, China

10.1016/j.partic.2018.05.008

Volume 44, June 2019, Pages 136-145

Received 31 January 2018, Revised 9 April 2018, Accepted 3 May 2018, Available online 4 December 2018, Version of Record 30 April 2019.

E-mail: caijie@njnu.edu.cn; c.y.wu@surrey.ac.uk

Highlights

• The force distribution on retinal cells in the injectors with two needle shapes was analysed.

• DEM–CFD incorporating with immersed boundary method was used to model the cell–fluid flow.

• The force distribution of retinal cells in straight and curved needles was different.

Abstract

Direct injection of retinal cells into patients’ eyes is a new and improved therapeutic method to address cataracts, but one challenge is that the survival rate of cells during injection is very low. To solve this problem, in this study, the force distribution on retinal cells in injectors with two needle shapes was analysed by coupling the discrete element method with computational fluid dynamics and implementation of an immersed boundary method. Two injectors were considered: one with a straight needle and the other with a curved needle. The velocities of retinal cells in the injector with a straight needle were slightly higher than those in the injector with a curved needle. In addition, injection speed greatly affected the force distribution on retinal cells, with the retinal cells near the piston subjected to the highest forces during injection. The forces on retinal cells strengthened with increases in both retinal cell concentration and piston displacement.

Graphical abstract

Keywords

Retinal cells; Force distribution; Injection; DEM–CFD; Immersed boundary method

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