On the stability of Würster fluid bed of pharmaceutical pellets--颗粒学报PARTICUOLOGY

Foroughi-Dahr, M., Sotudeh-Gharebagh, R., & Mostoufi, N. (2019). On the stability of Würster fluid bed of pharmaceutical pellets. Particuology, 45, 81-90. https://doi.org/10.1016/j.partic.2018.05.003

On the stability of Würster fluid bed of pharmaceutical pellets

Mohammad Foroughi-Dahr, Rahmat Sotudeh-Gharebagh ^*, Navid Mostoufi

Multiphase Systems Research Lab, School of Chemical Engineering, College of Engineering, University of Tehran, P.O. Box 11365/4563, Tehran, Iran

10.1016/j.partic.2018.05.003

Volume 45, August 2019, Pages 81-90

Received 6 February 2018, Revised 25 April 2018, Accepted 1 May 2018, Available online 23 October 2018, Version of Record 10 June 2019.

E-mail: sotudeh@ut.ac.ir

Highlights

• Three different flow regimes were detected using PSDFs of pressure fluctuations.

• Slow movement of pellets in annulus lies in the frequency ranges less than 5 Hz.

• Bulk movement of pellets inside the draft tube occurs at the frequencies at about 8 Hz.

• Horizontal movement of pellets through entrainment zone has the frequency at about 13 Hz.

• A new correlation was proposed predicting minimum spouting velocity of a Würster apparatus.

Abstract

The flow of pharmaceutical pellets in a Würster fluid bed (WFB) was characterized by a frequency domain analysis of pressure fluctuations. Pellets with a diameter of 0.780 mm and density of 1.225 kg/m³ were used in the experiments. Different flow structures were identified in the bed, including bulk movement of pellets in the annulus (f < 5 Hz), bulk movement of pellets inside the draft tube and bulk horizontal movement of pellets through the entrainment zone (5 < f < 15 Hz), and clustering (15 < f < 145 Hz). The minimum spouting velocity was also measured experimentally. Effects of bed height, distance of the entrainment zone, and distributor hole pitch on minimum spouting velocity were investigated. It was found that the minimum spouting velocity increased with increasing bed height and distance of the entrainment zone while it decreased with increasing distributor hole pitch. A correlation was developed for estimating the minimum spouting velocity in WFBs containing pharmaceutical pellets. The correlation fit the experimental data satisfactorily. Studying the WFB hydrodynamics and determining the minimum spouting velocity provides information that can be used to properly design, operate, and scale up such systems.

Graphical abstract

Keywords

Pharmaceutical pellets; Würster fluid bed; Draft tube; Minimum spouting velocity

文章导读