Mesoscale regulation of droplet templates to tailor microparticle structures and functions--颗粒学报PARTICUOLOGY

Peng, H.-Y., Wang, W., Xie, R., Ju, X.-J., Liu, Z., Faraj, Y., & Chu, L.-Y. (2020). Mesoscale regulation of droplet templates to tailor microparticle structures and functions. Particuology, 48, 74-87. https://doi.org/10.1016/j.partic.2018.10.003

Mesoscale regulation of droplet templates to tailor microparticle structures and functions

Han-Yu Peng ^a, Wei Wang ^{a b *}, Rui Xie ^{a b}, Xiao-Jie Ju ^{a b}, Zhuang Liu ^{a b}, Yousef Faraj ^a, Liang-Yin Chu ^{a b *}

a School of Chemical Engineering, Sichuan University, Chengdu 610065, Sichuan, China
b State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, Sichuan, China

10.1016/j.partic.2018.10.003

Volume 48, February 2020, Pages 74-87

Received 6 August 2018, Revised 1 October 2018, Accepted 24 October 2018, Available online 25 March 2019, Version of Record 27 January 2020.

E-mail: wangwei512@scu.edu.cn; chuly@scu.edu.cn

Highlights

• Mesoscale structures can be regulated in the droplet templates.

• The mesoscale structure determines the microparticle structure and function.

• The mesoscale structures affect droplet morphology and stability.

• The mesoscale structure can be controlled via mass transfer or chemical reaction.

Abstract

The hierarchical design of mesoscale structures in droplet templates determines the structure and functionality of the resultant microparticles. In this review, we summarize recent progress on the control of microfluidic emulsion templates for the synthesis of polymeric microparticles with desired functionality and internal structure. We introduce strategies for controlling the morphology and interfacial stability of emulsion templates. These strategies are based on manipulation of the mesoscale structure of amphiphilic molecules and nanoparticles at emulsion-droplet interfaces. We also discuss strategies for controlling the mesoscale structure of microparticles, which involve manipulating the interfacial mass-transfer and chemical reactions during template synthesis. We provide insight on the use of these strategies for the rational design and fabrication of polymeric microparticles with predictable internal structures and functionality at the single-particle level.

Graphical abstract

Keywords

Functional microparticles; Emulsion droplets; Mesoscale structures; Microfluidics; Template synthesis

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