Eco-friendly method for synthesis of zeolitic imidazolate framework 8 decorated graphene oxide for antibacterial activity enhancement--颗粒学报PARTICUOLOGY

Ahmad, N., Md Nordin, N. A. H., Jaafar, J., Nik Malek, N. A. N., Ismail, A. F., Yahya, M. N. F., . . . Abdullah, M. S. (2020). Eco-friendly method for synthesis of zeolitic imidazolate framework 8 decorated graphene oxide for antibacterial activity enhancement. Particuology, 49, 24-32. https://doi.org/10.1016/j.partic.2019.04.007

Eco-friendly method for synthesis of zeolitic imidazolate framework 8 decorated graphene oxide for antibacterial activity enhancement

Nazerah Ahmad ^{a b}, Nik Abdul Hadi Md Nordin ^c, Juhana Jaafar ^a, Nik Ahmad Nizam Nik Malek ^e, Ahmad Fauzi Ismail ^a^*, Muhammad Nabil Fikri Yahya ^d, Siti Aishah Mohd Hanim ^e, Mohd Sohaimi Abdullah ^a

a Advanced Membrane Technology Research Centre, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
b Malaysian Institute of Chemical Engineering Technology-Universiti Kuala Lumpur, Lot 1988, Bandar Vendor, Taboh Naning, 78000 Alor Gajah, Melaka, Malaysia
c Chemical Engineering Department, Universiti Teknologi PETRONAS, 32610 Seri Iskandar, Perak, Malaysia
d Centre for Student Innovation and Technology Entrepreneurship, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia
e Department of Biosciences, Faculty of Science, Universiti Teknologi Malaysia, 81310 Skudai, Johor, Malaysia

10.1016/j.partic.2019.04.007

Volume 49, April 2020, Pages 24-32

Received 14 January 2019, Revised 11 March 2019, Accepted 13 April 2019, Available online 15 July 2019, Version of Record 26 February 2020.

E-mail: afauzi@utm.my

Highlights

• Zeolitic imidazolate framework 8 (ZIF-8)–graphene oxide composites was synthesized.

• Composites exhibit strong antibacterial activity against E. coli and S. aureus bacteria.

• Antibacterial activity of ZIF-8 increases 5 times with addition of graphene oxide.

• Antibacterial activity caused by zinc ions release and composite accumulation in cell wall.

Abstract

We report a rapid method for synthesis of zeolitic imidazolate framework 8 (ZIF-8)-decorated graphene oxide (GO) composites (ZGO) with good antibacterial properties. The ZGO composites were synthesized at room temperature with low GO to metal salt ratios. The samples were characterized by X-ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, thermal gravimetric analysis, and surface area analysis. The characterization results show that ZIF-8 with a size of approximately 120 nm is successfully decorated on the surface of GO sheets with the host ZIF-8 framework maintained in the synthesized composite, but there is a significant reduction in the Brunauer–Emmett–Teller surface area. The antibacterial activities of the samples against Escherichia coli ATCC 11229 and Staphylococcus aureus ATCC 6538 as model strains of gram-negative and -positive bacteria, respectively, were determined by disc diffusion and minimum inhibitory concentration (MIC) tests. ZGO-1.0 (1 wt% of ratio of GO to metal salt) shows the highest antibacterial activity with MIC values required to inhibit bacterial growth of E. coli and S. aureus of 5 times lower than those of pristine ZIF-8. Different antibacterial mechanisms are proposed based on field-emission scanning electron microscope images of the two bacteria after contact with the synthesized composite. Overall, owing to the simple synthesis, good stability, low chemical usage, and excellent antibacterial activity of the ZGO composites, they show great potential for application in the field of microbial contamination control.

Graphical abstract

Keywords

Graphene oxide; Metal–organic framework; Hybrid nanocomposite; Zeolitic imidazolate framework; Antibacterial agent

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