The influence of porosity on tablet subdivision--颗粒学报PARTICUOLOGY

Teixeira, M. T., Sa-Barreto, L. L., Silva, I. C., Gratieri, T., Gelfuso, G. M., Marreto, R. N., . . . Cunha-Filho, M. (2020). The influence of porosity on tablet subdivision. Particuology, 53, 192-196. https://doi.org/10.1016/j.partic.2020.06.001

The influence of porosity on tablet subdivision

Maíra T. Teixeira ^a, Livia L. Sa-Barreto ^a, Izabel C. Silva ^a, Tais Gratieri ^a, Guilherme M. Gelfuso ^a, Ricardo N. Marreto ^b, Mariana Landin ^c, Marcilio Cunha-Filho^a *

a Laboratory of Food, Drugs and Cosmetics (LTMAC), University of Brasília (UnB), 70910-900 Brasília, DF, Brazil
b Laboratory of Nanosystems and Drug Delivery Devices (NanoSYS), Federal University of Goiás, Goiânia, GO, Brazil
c Departamento de Farmacología, Farmacia y Tecnología Farmacéutica, I+D Farma Group (GI-1645), Universidade de Santiago de Compostela, Spain

10.1016/j.partic.2020.06.001

Volume 53, December 2020, Pages 192-196

Received 16 March 2020, Revised 23 May 2020, Accepted 7 June 2020, Available online 8 July 2020, Version of Record 16 December 2020.

E-mail: marciliofarm@hotmail.com

Highlights

• Tablets of increasing porosity were achieved in the presence of a sublimable agent.

• A tablet porosity >90% led to inadequate subdivision outcomes.

• Irregular pore size distribution resulted in subdivision failure.

• Tablets having a subdivision purpose should have controlled porosity.

Abstract

A tablet microstructure, especially the porosity, is a crucial parameter that influences the mechanical properties. Herein, tablet subdivisions were studied as a function of tablet porosity. The tablets were manufactured in the presence of different diluents, namely microcrystalline cellulose, Ludipress®, or lactose monohydrate. Furthermore, the addition of Camphor was investigated, which was thereafter sublimated with a view of obtaining tablets having varying degrees of porosity. Microstructural assays were correlated to the subdivision performance. The increase in porosity reduced the hardness and increased the tablet friability, adversely impacting the subdivision. For all the excipients, an increase in relative porosity >90% represented the threshold level from which an inadequate subdivision occurred. The increase in tablet porosity led to a reduction in mechanical resistance, which, combined with a heterogeneous and discontinuous distribution of pores within the matrix, resulted in poor subdivision results. Controlling tablet porosity is an important consideration when designing tablets having a subdivision purpose.

Graphical abstract

Keywords

Tablet subdivision; Porosity; Mass variation; Mass loss; Friability; Hardness

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