Influence of microwave drying and conventional drying methods on the mechanical properties of naproxen sodium drug tablets--颗粒学报PARTICUOLOGY

Al-Ali, M., & Parthasarathy, R. (2020). Influence of microwave drying and conventional drying methods on the mechanical properties of naproxen sodium drug tablets. Particuology, 53, 30-40. https://doi.org/10.1016/j.partic.2020.01.006

Influence of microwave drying and conventional drying methods on the mechanical properties of naproxen sodium drug tablets

Maha Al-Ali, Rajarathinam Parthasarathy ^*

Chemical and Environmental Engineering, School of Engineering, RMIT University, Melbourne, Victoria 3001, Australia

10.1016/j.partic.2020.01.006

Volume 53, December 2020, Pages 30-40

Received 22 September 2019, Revised 16 January 2020, Accepted 27 January 2020, Available online 1 April 2020, Version of Record 16 December 2020.

E-mail: rchrp@rmit.edu.au

Highlights

• Microwave dried tablets exhibit the second-highest tensile strength and hardness.

• The friability of tablets subjected to microwave drying is within accepted limits.

• Naproxen sodium tablets produced using microwave drying have acceptable mechanical properties.

• Enhancement or degradation in the mechanical properties of tablets depends on the drying method used.

Abstract

Tablets are one of the most commonly used solid dosage forms taken by patients. The preparation of high-quality tablets requires an understanding of the preparation process and elucidation of how the physical and mechanical properties change as a function of the preparation process. This work aims to investigate the impact of microwave irradiation drying and conventional drying methods (including freeze, convective and vacuum drying) on the hardness, tensile strength and friability of tablets made from a multi-component formulation containing naproxen sodium, microcrystalline cellulose, and polyvinylpyrrolidone. The results show that tablets subjected to microwave drying had the second-highest tensile strength and hardness of 1.296 MPa and 67 N, respectively. The tablets subjected to vacuum drying had the lowest tensile strength and hardness of 1.21 MPa and 64 N, respectively. The friability index values for the tablets derived from the microwave and freeze-drying methods were <1%, while those for the tablets subjected to convective drying and vacuum drying methods were>1%. Microwave drying was observed to be an efficient method to produce naproxen sodium-containing tablets with satisfactory mechanical properties. These findings confirm that the drying method plays an essential role in the improvement or degradation of the mechanical properties of tablets.

Graphical abstract

Keywords

Microwave drying; Naproxen sodium; Hardness; Friability; Tensile strength

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