Synthesizing molecularly imprinted polymer beads for the purification of vitamin E--颗粒学报PARTICUOLOGY

hang, Y., Zhu, Y., Loo, L. S., Yin, J., & Wang, K. (2021). Synthesizing molecularly imprinted polymer beads for the purification of vitamin E. Particuology, 57, 10-18. https://doi.org/10.1016/j.partic.2020.12.009

Synthesizing molecularly imprinted polymer beads for the purification of vitamin E

Youhong Zhang ^{a b *}, Yinpei Zhu ^{a b}, Leslie S. Loo ^c, Jianguo Yin ^d, Kean Wang ^e *

a School of Environmental Ecology and Biological Engineering, Wuhan Institute of Technology, Wuhan 430205, PR China
b Key Laboratory for Green Chemical Process of Ministry of Education, Wuhan Institute of Technology, Wuhan 430205, PR China
c Singapore Institute of Technology, 10 Dover Drive, 138683 Singapore
d Jiangsu Xixin Vitamin Co., Ltd., Jiangsu 223600, PR China
e Center for Catalysis and Separation (CeCAS), Chemical Engineering Department, Khalifa University of Science & Technology, Abu Dhabi, United Arab Emirates

10.1016/j.partic.2020.12.009

Volume 57, August 2021, Pages 10-18

Received 13 October 2020, Revised 6 December 2020, Accepted 13 December 2020, Available online 27 January 2021, Version of Record 22 February 2021.

E-mail: youhong@wit.edu.cn； kean.wang@ku.ac.ae

Highlights

• Molecularly imprinted polymers were obtained from MAA on a PS substrate.

• This material showed a high vitamin E adsorption capacity of 46 mg/g.

• Superior performance to non-imprinted polymers was obtained.

• Comparable performance to precipitation polymerization materials was obtained.

• This material provides facile elution and can be regenerated.

Abstract

Molecularly imprinted polymer (MIP) beads imprinted with vitamin E (VE) were synthesized via a two-step swelling polymerization method, using methacrylic acid (MAA) and other functional monomers together with polystyrene (PS) microspheres as the substrate. In initial trials, different functional monomers were assessed, along with a variety of solvents and imprinting ratios. The MIPMAA sample exhibited the highest performance and was characterized and also assessed with regard to VE adsorption under various experimental conditions. This material exhibited reasonably good sphericity, porosity and stability, along with an excellent adsorption capacity of 46 mg/g. This was much higher than the value for the corresponding non-imprinted polymer made with the same monomer, and 20% higher than that for an acrylamide-based MIP synthesized using a precipitation polymerization method. The core-shell structured MIPMAA also demonstrated fast adsorption kinetics, a low pressure drop and good reusability in fixed bed experiments. The VE adsorption equilibrium, selectivity, kinetics, thermodynamics and regeneration capacity of this material were also examined and are reported herein.

Graphical abstract

Keywords

Vitamin E; α-Tocopherol; MIP; Molecularly imprinting; Adsorption; Separation

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