Biomolecule@COF: Natural-artificial hybrid microcapsules for controllable biocatalysis (Open Access)--颗粒学报PARTICUOLOGY

Qiao, S., Li, M., Yu, J., Zhang, S., Yan, D., Zhang, Z., & Chen, Y. (2022). Biomolecule@COF: Natural-artificial hybrid microcapsules for controllable biocatalysis. Particuology, 64, 140-144. https://doi.org/10.1016/j.partic.2021.03.002

Biomolecule@COF: Natural-artificial hybrid microcapsules for controllable biocatalysis (Open Access)

Shan Qiao^{a 1}, Mingmin Li ^{b 1}, Jiangyue Yu ^a, Sainan Zhang ^a, Dong Yan ^c, Zhenjie Zhang ^c, Yao Chen ^a *

a State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, China
b Life and Health Research Institute, School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China
c College of Chemistry, Nankai University, Tianjin 300071, China

10.1016/j.partic.2021.03.002

Volume 64, May 2022, Pages 140-144

Received 31 January 2021, Revised 1 March 2021, Accepted 2 March 2021, Available online 18 March 2021, Version of Record 17 December 2021.

E-mail: chenyao@nankai.edu.cn

Highlights

• A natural-artificial hybrid prototype of Cyt c@COF-42-B particles was fabricated.

• The hydrophilic pore microenvironment of particles was precisely controlled.

• The catalytic performance of the composites was enhanced.

Abstract

The assembly of biomacromole particles with artificial solid matrixes to fabricate hybrid composites has been demonstrated as an efficient strategy to promote both components’ applications. Elaborating matrixes as well as appropriate assembly method is essential for optimal performances of the obtained natural-artificial composites. Herein, we fabricated the Cyt c@COF-42-B microcapsule through a sacrificial templating method and researched their adjustable biocatalysis by precisely adjusting the microenvironments of these assembled enzyme@COF particles. As a result, the hydrophobicity and mass transfer of the COF microcapsule can be controlled by modifying the different amounts of PEG moieties, thus improving the composite's bioactivity. We found that compared with pristine Cyt c@COF-42-B without PEG, the Cyt c@COF-42-B-PEG exhibited a ∼2.2 times higher activity. This study provides a significant step toward designing customizable functional natural-artificial composites for enhanced biomacromolecule's activity.

Graphical abstract

Keywords

Biomolecule; COFs; Immobilization; Capsules; Controllable catalysis

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