Enzyme–metal nanocomposites for antibacterial applications (Open Access)--颗粒学报PARTICUOLOGY

Xiong, J., Cai, X., & Ge, J. (2022). Enzyme–metal nanocomposites for antibacterial applications. Particuology, 64, 134-139. https://doi.org/10.1016/j.partic.2021.02.003

Enzyme–metal nanocomposites for antibacterial applications (Open Access)

Jiarong Xiong ^a, Xinyi Cai ^a, Jun Ge ^{a b *}

a Key Lab for Industrial Biocatalysis, Ministry of Education, Department of Chemical Engineering, Tsinghua University, Beijing 100084, China
b Institute of Biopharmaceutical and Health Engineering, Tsinghua Shenzhen International Graduate School, Shenzhen 518055, China

10.1016/j.partic.2021.02.003

Volume 64, May 2022, Pages 134-139

Received 26 December 2020, Revised 28 January 2021, Accepted 15 February 2021, Available online 18 March 2021, Version of Record 17 December 2021.

E-mail: junge@mail.tsinghua.edu.cn

Highlights

• Enzyme–metal nanocomposites (NCs) are alternatives to antibiotics.

• Enzyme–metal NCs have synergistic bactericidal effect with higher biocompatibility.

• Enzymes act as reductants, stabilizers and decrease the dosages of metal nanoparticles.

• The main preparations are co-immobilization and in situ reduction.

Abstract

Metal nanoparticles have been used as antibacterial agents widely, and the combined use of enzymes and metal nanoparticles promotes antibacterial activity, achieving a synergistic effect. Additionally, enzymes decrease the amounts of metals and increase biocompatibility, thereby reducing toxicity of metals. However, the efficiency of enzymes is hindered when coupled with metals, which causes deactivation in the function of enzymes. How can a balance be struck between metals and enzymes? Although the antibacterial mechanism of metal nanoparticles is relatively clear, how enzyme–metal nanocomposites work against bacteria is not conclusive. Here, we describe several examples on the synthesis of enzyme–metal nanocomposites via co-immobilization or in situ reduction and summarize how enzyme–metal nanocomposites combat microorganisms.

Graphical abstract

Keywords

Enzyme–metal nanocomposites; Applications; Preparations; Antibacterial mechanisms

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