Nanoemulsions for drug delivery (Open Access)--颗粒学报PARTICUOLOGY

Wilson, R. J., Li, Y., Yang, G., & Zhao, C.-X. (2022). Nanoemulsions for drug delivery. Particuology, 64, 85-97. https://doi.org/10.1016/j.partic.2021.05.009

Nanoemulsions for drug delivery (Open Access)

Russell J. Wilson, Yang Li, Guangze Yang, Chun-Xia Zhao ^*

Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia Queensland 4072, Australia

10.1016/j.partic.2021.05.009

Volume 64, May 2022, Pages 85-97

Received 29 March 2021, Revised 24 May 2021, Accepted 26 May 2021, Available online 8 June 2021, Version of Record 17 December 2021.

E-mail: z.chunxia@uq.edu.au

Highlights

• Overview of nanoemulsions for drug delivery.

• Summary of different emulsion systems.

• Discussion about nanoemulsion preparation and stability.

• Introduction of different types of surfactants.

• Emulsion nanomedicine and their clinical applications.

Abstract

Emulsions are liquid–liquid dispersions with one liquid phase dispersed in the other liquid phase as small droplets. Nanoemulsions are nano-sized emulsions with sizes ranging from tens to hundreds of nanometers, and have great potential applications in pharmaceutics, foods and cosmetics due to their attractive properties, such as small sizes, high surface area per unit volume, improved dispersion of active hydrophobic components and enhanced absorption. The article provides an overview of nanoemulsions for drug delivery, starting with an introduction of emulsion types, nanoemulsion preparation and nanoemulsion stability. Surfactants play critical roles in producing and stabilizing nanoemulsions. Different types of surfactants are summarized including small molecule surfactants, particle surfactants, phospholipids, peptide and protein surfactants. Then the applications of nanoemulsions as nanomedicine in drug delivery are presented. Finally, clinical applications of nanoemulsions are discussed.

Graphical abstract

Keywords

Nanoemulsions; Surfactants; Drug delivery; Nanomedicine; Peptide surfactant

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