Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy (Open Access)--颗粒学报PARTICUOLOGY

Xiang, W., Liu, X., Zhang, L., Liu, C., & Liu, G. (2022). Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy. Particuology, 64, 35-42. https://doi.org/10.1016/j.partic.2021.04.017

Cell membrane-encapsulated nanoparticles for vaccines and immunotherapy (Open Access)

Wei Xiang ^{a 1}, Xue Liu ^{b 1}, Lili Zhang ^a, Chao Liu ^{a c *}, Gang Liu ^a *

a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
b State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics and National Institute of Diagnostics and Vaccine Development in Infectious Disease, School of Public Health, Xiamen University, Xiamen 361102, China
c ShenZhen Research Institute of Xiamen University, Shenzhen 518057, China

10.1016/j.partic.2021.04.017

Volume 64, May 2022, Pages 35-42

Received 11 February 2021, Revised 14 April 2021, Accepted 29 April 2021, Available online 23 May 2021, Version of Record 17 December 2021.

E-mail: liuchao66888@163.com; gangliu.cmitm@xmu.edu.cn

Highlights

• Cell membrane coating technologies bestow nanocarriers with natural capability.

• A variety of cell types can be used as sources of membranes to load nanoparticles.

• Diversity of cell membranes and nanocarriers enables extensive applicability.

• Cell membrane-coated nanoparticles will achieve promotion in clinical application.

Abstract

Functionalized nanoparticles are widely used in drug targeted delivery and immune microenvironment regulation. As a new type of biomaterial, cell-derived carriers are receiving considerable attention in clinical translation owing to their desirable biocompatibility and lower toxicity. Importantly, cell membrane-encapsulated nanoparticles can achieve specific biological effects from the benefit of their parent cell characteristics. In this review, we introduce the cell membrane coating technologies that are under extensive investigation, we also summarize various applications that have been developed for immunotherapy, and discuss the prospects in this field. With further understanding and integration with advanced biotechnology methods, it is believed that the continuing development of cell membrane-encapsulated nanoparticles will achieve promotion in clinical application.

Graphical abstract

Keywords

Cell membrane; Nanoparticle; Vaccine; Immunotherapy

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