Application of solvent evaporation technique for pure drug crystal spheres preparation--颗粒学报PARTICUOLOGY

Mady, O. (2022). Application of solvent evaporation technique for pure drug crystal spheres preparation. Particuology, 67, 79-89. https://doi.org/10.1016/j.partic.2021.09.011

Application of solvent evaporation technique for pure drug crystal spheres preparation

Omar Mady ^*

Department of Pharmaceutical Technology, Faculty of Pharmacy, Tanta University, Egypt

10.1016/j.partic.2021.09.011

Volume 67, August 2022, Pages 79-89

Received 16 March 2021, Revised 30 August 2021, Accepted 18 September 2021, Available online 27 October 2021, Version of Record 3 December 2021.

E-mail: Omer.Mady@gmx.at

Highlights

• Drug crystal spheres were prepared using drug encapsulation technique as a novel application.

• Ibuprofen was selected as a model drug.

• Hydrophilic colloid should be used at a high concentration.

• Low or high HLB surfactant did not produce drug crystal spheres.

Abstract

An innovative application of the solvent evaporation technique was suggested. Solvent evaporation technique is a technique for drug encapsulation and nanosphere preparation. The widely used technique is also facing the problem of low actual drug entrapment percent, which is not economic from the industrial view. The goal of this work is trying to use the advantage of this technique concerning the product sphericity and the ability to control particle size, to prepare a drug as pure crystals spheres. Ibuprofen is selected as a model drug. The spheres are formed by using Polyvinyl pyrrolidone (PVP) or Polyethylene glycol (PEG) as an anti-aggregating agent but not formed on using tween or span. Particle size and actual drug content depend on the concentrations the anti-aggregating agent used. Surfaces of the drug crystal spheres are porous with empty sphere internal structure on using PVP but spongy and rough on using PEG. The drug has its identity chemical form in the drug crystal spheres. IR scan of spheres prepared on using PEG showed a characteristic ether peak. DSC showed melting endothermic peak of PEG, but X-ray showed minor change in the drug crystal patterns. Drug release profiles from crystal spheres prepared with the same anti-aggregating agent are close to each other. The drug release profiles from drug crystal spheres prepared by using PEG are more controlled than that prepared by using PVP. The drug release mechanism is diffusion. It was concluded that, the same technique could be suggested for preparation of other biomedical material in pure crystals spheres with controlled particle size. These properties may encourage to prepare very small particles with spherical shape for inhalation or injection as an innovative particle technology application for the widely used technique.

Graphical abstract

Keywords

Solvent evaporation technique; Drug crystal spheres; Ibuprofen; Polyvinyl pyrrolidone; Polyethylene glycol

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