Shell-formation mediated surface composition of uniform two-component microparticles fabricated by micro-fluidic spray drying: Effect of component size and solubility--颗粒学报PARTICUOLOGY

Ma, X., Yan, S., Zhang, S., Yin, Q., Chen, X., & Wu, W. D. (2022). Shell-formation mediated surface composition of uniform two-component microparticles fabricated by micro-fluidic spray drying: Effect of component size and solubility. Particuology, 67, 68-78. https://doi.org/10.1016/j.partic.2021.10.005

Shell-formation mediated surface composition of uniform two-component microparticles fabricated by micro-fluidic spray drying: Effect of component size and solubility

Xiaoqian Ma, Shen Yan, Shengyu Zhang, Quanyi Yin ^*, Xiaodong Chen, Winston Duo Wu ^*

Engineering Research Centre of Advanced Powder Technology (ERCAPT), School of Chemical and Environmental Engineering, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

10.1016/j.partic.2021.10.005

Volume 67, August 2022, Pages 68-78

Received 6 September 2021, Revised 16 October 2021, Accepted 17 October 2021, Available online 1 November 2021, Version of Record 2 December 2021.

E-mail: qyyin@suda.edu.cn; duo.wu@suda.edu.cn

Highlights

• Uniform two-component particles were fabricated via micro-fluidic spray drying.

• Component size and solubility were shown to have significant impact on surface composition.

• Construction of semi-dried shell was essential for mediating surface composition.

•“Convection/diffusion-controlled surface rearrangement” was proposed.

• Particle wettability was well correlated with respective surface composition.

Abstract

This work is aimed to study the effects of component size and solubility on the surface composition of spray dried (SD) uniform two-component particles fabricated by micro-fluidic spray dryer. Various precursor liquid consisting of small molecular of methionine (Met, 33 g/L) or lysine (Lys, 739 g/L) and large-sized silica (12 nm) were prepared by adjusting the mass ratio of components. X-ray energy dispersive results showed that the respective enrichment degree (De) of Met and Lys on the surface of SD-M1S9 and -L1S9 prepared at 150 °C were 182 ± 9% and 125 ± 14%. The De of hydrophobic Met for SD-M1S1 and -M9S1 were 46 ± 9% and 4 ± 2%, respectively, whereas relative hydrophilic Lys mainly distributed internal of the particle meanwhile the De of silica on the surface for SD-L1S1 and -L9S1 were 17 ± 4% and 12 ± 1%, respectively. Drying temperature (120 and 180 °C) showed more apparent effect on the De of amino acid for the particles of less amino acid. The possible formation mechanism of surface composition and the surface composition impact on the wettability of particles were explored. These results provide new guidance for manufacturing functional SD powders with various components.

Graphical abstract

Keywords

Spray drying; Uniform microparticles; Two-component; Surface composition; Size; Solubility

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