Toxicity of manufactured nanomaterials (Open Access)--颗粒学报PARTICUOLOGY

Liu, Y., Zhu, S., Gu, Z., Chen, C., & Zhao, Y. (2022). Toxicity of manufactured nanomaterials. Particuology, 69, 31-48. https://doi.org/10.1016/j.partic.2021.11.007

Toxicity of manufactured nanomaterials (Open Access)

Yaping Liu^{a b}, Shuang Zhu^{a c}, Zhanjun Gu^{a c *}, Chunying Chen^{a c d *}, Yuliang Zhao^{a b c d *}

a CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China and Institute of High Energy Physics, Beijing 100190, China
b The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China
c College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China
d GBA Research Innovation Institute for Nanotechnology, Guangzhou 510700, China

10.1016/j.partic.2021.11.007

Volume 69, October 2022, Pages 31-48

Received 25 October 2021, Revised 18 November 2021, Accepted 23 November 2021, Available online 29 November 2021, Version of Record 15 December 2021.

E-mail: zjgu@ihep.ac.cn; chenchy@nanoctr.cn; zhaoyl@nanoctr.cn

Highlights

• How key toxicity-associated nanomaterial properties impact nano-bio interactions is discussed.

• Analytical methods for studying nano-bio interactions are presented.

• Current regulatory and legislative frameworks regulating nanomaterials are introduced.

• Challenges facing nanomaterials' safety evaluation and possible solutions are given.

Abstract

Manufactured nanomaterials with unique properties have been extensively applied in various industrial, agricultural or medical fields. However, some of the properties have been identified to be closely related to nanomaterial toxicity. The "nano-paradox" has aroused concerns over the use and development of nanotechnology, which makes it difficult for regulatory agencies to regulate nanomaterials. The key to fulfilling proper nanomaterial regulation lies in the adequate understanding of the impact of nanomaterial properties on nano-bio interactions. To this end, we start the present work with a brief introduction to nano-bio interactions at different levels. Based on that, how key toxicity-associated properties of manufactured nanomaterials (i.e., size, shape, chemical composition, surface properties, biocorona formation, agglomeration and/or aggregation state, and biodegradability) impact their toxicokinetics, cellular uptake, trafficking and responses, and toxicity mechanisms is deeply explored. Moreover, advanced analytical methods for studying nano-bio interactions are introduced. Furthermore, the current regulatory and legislative frameworks for nanomaterial-containing products in different regions and/or countries are presented. Finally, we propose several challenges facing the nanotoxicology field and their possible solutions to shed light on the safety evaluation of nanomaterials.

Graphical abstract

Keywords

Manufactured nanomaterial; Nanotoxicity; Nano-bio interaction; Nanomaterial property; Analytical method; Regulation

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