Metal-based nanoparticles for cardiovascular disease diagnosis and therapy--颗粒学报PARTICUOLOGY

Li, L., Zeng, Y., & Liu, G. (2023). Metal-based nanoparticles for cardiovascular disease diagnosis and therapy. Particuology, 72, 94-111. https://doi.org/10.1016/j.partic.2022.03.002

Metal-based nanoparticles for cardiovascular disease diagnosis and therapy

Lei Li ^a *, Yun Zeng ^b, Gang Liu ^a *

a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China
b Department of Pharmacy, Xiamen Medical College, Xiamen 361023, China

10.1016/j.partic.2022.03.002

Volume 72, January 2023, Pages 94-111

Received 1 February 2022, Revised 26 February 2022, Accepted 1 March 2022, Available online 12 March 2022, Version of Record 7 May 2022.

E-mail: li.lei@xmu.edu.cn; gangliu.cmitm@xmu.edu.cn

Highlights

• Physicochemical and biological properties of metal-based nanoparticles and their application in cardiovascular diseases.

• Impact and optimization of metal-based nanoparticles for cardiovascular disease imaging and therapy.

• Potential risks of metal-based nanomaterial for cardiovascular disease applications.

Abstract

Cardiovascular diseases (CVDs) are the most prominent cause of disability and mortality in the world. Although there have been a variety of therapeutic options for the management of CVDs, most of the traditional therapeutic strategies could not sufficiently stop or reduce the progression of these diseases and may result in some side effects. With the advance in nanotechnology, a number of metal-based nanoparticles have been developed and shown promising potentials in the treatment of CVDs. In this review, we provide a comprehensive review of researches on recent development of metal-based nanoparticles in diagnosis and therapy in CVDs as biomedical materials. We also discuss the challenges in the clinical translation and potential risks in their application of CVD therapy. Based on the ongoing research and applications, we can conclude metal-based nanoparticles are expected to become potential therapeutics for the treatment of CVDs. But their application is still in its infancy and much more efforts should be made to enforce a clinical breakthrough.

Graphical abstract

Keywords

Metal-based nanoparticles; Nanomedicine; Cardiovascular diseases; Diagnosis; Therapy

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