Kinetic study of complicated anti-solvent and cooling crystallization of disodium 5′-ribonucleotide--颗粒学报PARTICUOLOGY

Zhao, W., Li, B., Liu, S., Deng, Y., Zhang, R., & Jiang, Y. (2023). Kinetic study of complicated anti-solvent and cooling crystallization of disodium 5′-ribonucleotide. Particuology, 73, 103-112. https://doi.org/10.1016/j.partic.2022.05.001

Kinetic study of complicated anti-solvent and cooling crystallization of disodium 5′-ribonucleotide

Wang Zhao ^a, Binghui Li ^a, Shiyuan Liu^a, Yuehua Deng ^a, Rui Zhang ^{a b *}, Yanbin Jiang ^a^c *

a Guangdong Provincial Key Lab of Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China
b Zhuhai Institute of Modern Industrial Innovation, South China University of Technology, Zhuhai, 519175, China
c School of Chemical Engineering, Guangdong University of Petrochemical Technology, Maoming, 525000, China

10.1016/j.partic.2022.05.001

Volume 73, February 2023, Pages 103-112

Received 18 March 2022, Revised 28 April 2022, Accepted 3 May 2022, Available online 13 May 2022, Version of Record 24 May 2022.

E-mail: 0302zhangrui@163.com; cebjiang@scut.edu.cn

Highlights

• Crystallization of complicated IMP + GMP multi-solute in binary solvent was studied.

• Anti-solvent and cooling were both conducted considering the industrial conditions.

• Process analytical technology tools were used to obtain kinetic data of experiments.

• A modified kinetics model was developed which well fitted with the experiment data.

Abstract

Disodium 5′-ribonucleotide, which is composed of disodium 5′-inosine (IMP) and disodium 5′-guanosine (GMP), is an important food additive. The lack of kinetic studies of it causes a lack of clarity in understanding the complicated multi-solute crystallization of IMP + GMP in ethanol-water. In this work, process analytical technology tools were used to obtain the thermodynamics and kinetic data from the experiments, the kinetic parameters of anti-solvent and cooling crystallization were investigated. The crystal form of IMP + GMP mixed crystal was determined, which was consistent with the IMP whether crystallized from pure water or ethanol-water. The effects of different anti-solvent addition rates and cooling rates on the metastable zone widths were studied, and the opposite effect on metastable zone width was found. The modified exponential empirical function was developed to correlate nucleation and growth kinetic equations under different conditions. The kinetic data were well fitted with adjusted correlation coefficient (adj-R² > 0.7), which is sufficient to provide a valid reference for process design and control.

Graphical abstract

Keywords

Disodium 5′-ribonucleotide; Multi-solute crystallization; Nucleation and growth kinetics; Process analytical technology tools; Metastable zone width; Mixed crystal

文章导读