Near-infrared emissive AIE nanoparticles for biomedical applications: From the perspective of different nanocarriers (Open Access)--颗粒学报PARTICUOLOGY

Yan, D., Qin, Y., Yan, S., Sun, P., Wang, Y., Wang, D., & Tang, B. Z. (2023). Near-infrared emissive AIE nanoparticles for biomedical applications: From the perspective of different nanocarriers. Particuology, 74, 103-118. https://doi.org/10.1016/j.partic.2022.06.001

Near-infrared emissive AIE nanoparticles for biomedical applications: From the perspective of different nanocarriers (Open Access)

Dingyuan Yan^a, Yi Qin^a, Saisai Yan^a, Panpan Sun^a, Yuanwei Wang^a, Dong Wang ^a *, Ben Zhong Tang^{a b *}

a Center for AIE Research, Shenzhen Key Laboratory of Polymer Science and Technology, Guangdong Research Center for Interfacial Engineering of Functional Materials, College of Materials Science and Engineering, Shenzhen University, Shenzhen, 518060, Guangdong, China
b School of Science and Engineering, Shenzhen Institute of Aggregate Science and Technology, The Chinese University of Hong Kong, Shenzhen, 518172, Guangdong, China

10.1016/j.partic.2022.06.001

Volume 74, March 2023, Pages 103-118

Received 29 April 2022, Revised 28 May 2022, Accepted 1 June 2022, Available online 11 June 2022, Version of Record 24 June 2022.

E-mail: wangd@szu.edu.cn; tangbenz@cuhk.edu.cn

Highlights

• Aggregation-induced emission (AIE) nanoparticles sparkle in the field of biomedicine.

• Near-infrared fluorophores share the merits of high penetration depth.

• Different nanocarriers endow AIE-active nanoparticles versatile functionalities.

Abstract

Fluorescent imaging based on near-infrared (NIR) fluorophores has revolutionized the techniques employed for detecting biological events in depth owing to their advantages referring to diminished photon scattering, high signal-to-noise ratio and better light transparence through tissue. As for conventional luminogens, the nanofabrication of those innately hydrophobic π-conjugated architectures into water-dispersible nanoparticles (NPs) may result in attenuated fluorescent intensity deriving from the detrimental distribution of π-π interactions in the confined space. Oppositely, chromophores possessing aggregation-induced emission (AIE) characteristics emit boosted brightness at aggregate level according to the mechanism of restriction of intramolecular motion (RIM). In this review, we summarize the recent progresses of NIR emissive AIE NPs for multifarious biomedical applications from the viewpoint of different fabricated manners, mainly covering self-assembly and matrices assisted approaches. Furthermore, the current challenges and future research directions of NIR AIE NPs are briefly discussed.

Graphical abstract

Keywords

Aggregation-induced emission; Nanoparticles; Biomedical applications; Near-infrared emission; Nanocarriers

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