Modulation of reactive oxygen species to enhance sonodynamic therapy (Open Access)--颗粒学报PARTICUOLOGY

Liu, X., Pan, X., Wang, C., & Liu, H. (2023). Modulation of reactive oxygen species to enhance sonodynamic therapy. Particuology, 75, 199-216. https://doi.org/10.1016/j.partic.2022.08.001

Modulation of reactive oxygen species to enhance sonodynamic therapy (Open Access)

Xiaoyu Liu¹, Xueting Pan¹, Chaohui Wang, Huiyu Liu^*

Beijing Advanced Innovation Center for Soft Matter Science and Engineering, State Key Laboratory of Organic-Inorganic Composites, Beijing Laboratory of Biomedical Materials, Bionanomaterials & Translational Engineering Laboratory, Beijing Key Laboratory of Bioprocess, Beijing University of Chemical Technology, Beijing, 100029, China

10.1016/j.partic.2022.08.001

Volume 75, April 2023, Pages 199-216

Received 30 April 2022, Revised 22 July 2022, Accepted 2 August 2022, Available online 13 August 2022, Version of Record 26 August 2022.

E-mail: liuhy@mail.buct.edu.cn

Highlights

• Reactive oxygen species play an important role in sonodynamic therapy.

• The generation mechanisms of reactive oxygen species in sonodynamic therapy.

• The regulatory strategies of reactive oxygen species in sonodynamic therapy.

• Sonodynamic therapy combined with other treatment modalities based on reactive oxygen species.

Abstract

Reactive oxygen species (ROS), involving in many biological reactions, play an important role in disease treatment. Among the various ROS-based therapeutic modalities, sonodynamic therapy (SDT) stands out with its unique advantages. In turn, the SDT efficacy is mainly dependent on the ROS levels in the disease microenvironment. Therefore, in recent years, researchers have extensively investigated SDT with high ROS generation capacity. In this review, we focus on effective strategies to improve the therapeutic efficiency of SDT by modulating ROS, overview the basic mechanisms of ROS generation by sonosensitizers, highlight the rational design of sonosensitizers, and summarize strategies to improve the SDT efficacy by modulating disease microenvironment. In addition, multiple ROS synergistic treatment modalities and the prospect of SDT are discussed. We believe that the understanding and exploration of SDT enhancement strategies will facilitate the clinical translation of SDT.

Graphical abstract

Keywords

Reactive oxygen species; Sonodynamic therapy; Sonosensitizers; Oxidative stress; Combination therapy

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