Nanozymes for biomedical applications in orthopaedics (Open Access)--颗粒学报PARTICUOLOGY

Lin, A., Liu, S., & Wei, H. (2023). Nanozymes for biomedical applications in orthopaedics. Particuology, 76, 32-45. https://doi.org/10.1016/j.partic.2022.08.009

Nanozymes for biomedical applications in orthopaedics (Open Access)

Anqi Lin ^{a 1}, Shujie Liu ^{a 1}, Hui Wei ^{a b *}

a Department of Biomedical Engineering, College of Engineering and Applied Sciences, Nanjing National Laboratory of Microstructures, Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing, 210023, China
b State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing, 210023, China

10.1016/j.partic.2022.08.009

Volume 76, May 2023, Pages 32-45

Received 14 July 2022, Revised 11 August 2022, Accepted 17 August 2022, Available online 29 August 2022, Version of Record 14 September 2022.

E-mail: weihui@nju.edu.cn

Highlights

• Nanozymes have attracted considerable interests in biomedical applications.

• Nanozymes have been developed as therapeutic agents in orthopaedic diseases.

• Nanozymes shows great potential for more bone diseases along with challenges.

Abstract

As the next generation of artificial enzymes, nanozymes have attracted increasing attention in biomedical applications due to their multienzyme-like characteristics, multifunctionalities, low cost, and high stability. By taking advantage of their diverse activities, a growing number of nanozyme-mediated therapeutic strategies have been developed for various diseases. Herein, we provide a brief review of the representative studies of nanozymes, especially in orthopaedic diseases over the past decade, which include arthritis, osteoporosis, bone regeneration, bacteria-associated infections, and osteosarcoma. Moreover, the future potential applications and some major challenges are also discussed. This review would not only provide some instructive views of nanozymes but also promote the development of enzyme-mimetic strategies in orthopaedics.

Graphical abstract

Keywords

Nanozymes; Artificial enzymes; Orthopaedics; Nanomedicine; Nanomaterials

文章导读