Ultra-homogeneous Cu2−xSe nanoparticles as near-infrared II plasmonic phototheranstics for photothermal/chemodynamic synergistic therapy of liver cancer--颗粒学报PARTICUOLOGY

Li, B., Li, J., Fu, Y., Ye, X., Xie, M., Feng, L., . . . You, Z. (2023). Ultra-homogeneous Cu2−xSe nanoparticles as near-infrared II plasmonic phototheranstics for photothermal/chemodynamic synergistic therapy of liver cancer. Particuology, 76, 23-31. https://doi.org/10.1016/j.partic.2022.07.004

Ultra-homogeneous Cu_2−xSe nanoparticles as near-infrared II plasmonic phototheranstics for photothermal/chemodynamic synergistic therapy of liver cancer

Bei Li ^{a b}, Jing Li ^c , Yi Fu ^d, Xiwen Ye ^{a b}, Maodi Xie ^e, Lei Feng ^{a b}, Xiaoya Niu ^{a b}, Zhen You ^{a b *}

a Division of Biliary Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China
b Research Center for Biliary Diseases, West China Hospital, Sichuan University, Chengdu, 610041, China
c Department of Operating Room, West China Hospital of Sichuan University, Chengdu, 610041, China
d Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University, Beijing, 100191, China
e West China-Washington Mitochondria and Metabolism Center, West China Hospital of Sichuan University, Chengdu, 610041, China

10.1016/j.partic.2022.07.004

Volume 76, May 2023, Pages 23-31

Received 16 May 2022, Revised 5 July 2022, Accepted 6 July 2022, Available online 20 July 2022, Version of Record 14 September 2022.

E-mail: youzhen@wchscu.cn

Highlights

• A super-homogenous and highly dispersive spherical nanoparticle Cu_2-XSe was prepared.

• Nanoprobe displayed a strong (SPR) peak in the NIR-II and high Fenton catalytic efficiency.

• Nanoprobe could effectively inhibit tumor growth and exhibit good biocompatibility.

Abstract

Laser mediated photothermal/chemodynamic co-therapy is widely applied for anti-cancer treatment due to its good therapeutic effect. However, the laser wavelength for effectively targeting deep tumor tissues can decide whether or not it is a key premise of irradiation treatment. In this study, a super-homogenous and highly dispersive spherical nanoparticle Cu_2-XSe was prepared, which displayed a strong surface plasmon resonance (SPR) peak in the near-infrared region (NIR)-II and high Fenton catalytic efficiency. The results of in vitro experiments showed that Cu_2-XSe nanoparticles exhibited high photothermal conversion efficiency under the excitation of NIR-II laser irradiation, which significantly improved its ability to produce ·OH. In a tumor-bearing mouse model, the combination of Cu_2-XSe and photothermal/chemodynamic co-therapy guided by the real-time photoacoustic imaging in the NIR-II could effectively inhibit tumor growth and exhibit good in vivo/in vitro biocompatibility. In summary, this Cu_2-XSe nanoparticle-based NIR-II laser-mediated photothermal/chemodynamic co-therapy strategy is expected to provide a new option for the diagnosis and treatment of liver cancer.

Graphical abstract

Keywords

NIR-II; Cu_2-xSe; Photothermal therapy; Chemodynamic therapy; Liver cancer

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