A new track for antibacterial treatment: Progress and challenges of using cytomembrane-based vesicles to combat bacteria (Open Access)--颗粒学报PARTICUOLOGY

Xie, J., Liu, X., & Liu, G. (2023). A new track for antibacterial treatment: Progress and challenges of using cytomembrane-based vesicles to combat bacteria. Particuology, 78, 136-146. https://doi.org/10.1016/j.partic.2022.10.006

A new track for antibacterial treatment: Progress and challenges of using cytomembrane-based vesicles to combat bacteria (Open Access)

Jiaxuan Xie ^a, Xuan Liu ^{a b *}, Gang Liu ^{a b *}

a State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, School of Life Sciences, School of Public Health, Xiamen University, Xiamen, 361102, China
b Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China

10.1016/j.partic.2022.10.006

Volume 78, July 2023, Pages 136-146

Received 13 September 2022, Revised 16 October 2022, Accepted 19 October 2022, Available online 27 October 2022, Version of Record 20 February 2023.

E-mail: liuxuan@xmu.edu.cn; gangliu.cmitm@xmu.edu.cn

Highlights

• Cytomembrane-based vesicles receive considerable attention in disease therapy.

• The ability to interact with biological molecules underlie cytomembrane-based therapy.

• Various modifications bestow cytomembrane-based vesicles with antibacterial effect.

• Techniques cross amplifies the effect of cytomembrane-based vesicles.

Abstract

The emergence and re-emergence of antibiotic-resistant bacteria, especially superbugs, are leading to complicated infections that are increasingly difficult to treat. Therefore, novel alternative antimicrobial therapies are urgently needed to reduce the morbidity and mortality caused by antibiotic resistance. The development of biomimetic-based therapy is expected to provide innovative means for addressing this challenging task. As a kind of novel biomaterial, cytomembrane-based vesicles (MVs) continue to receive considerable attention in antimicrobial therapy owing to their inherent biocompatibility, design flexibility, and remarkable ability to interact with biological molecules or the surrounding environment. These remarkable cell-like properties and their inherent interaction with pathogens, toxins, and the immune system underlie MVs-based functional protein therapy and targeted delivery to develop advanced therapeutic strategies against bacterial infection. This review provides a fundamental understanding of the characteristics and physiological functions of cytomembrane-based vesicles, focusing on their potential to combat bacterial infections, including detoxification, immune modulation, antibiotics delivery, and physical therapy. In addition, the future possibilities and remaining challenges for clinically implementing MVs in the field of antibacterial treatment are discussed.

Graphical abstract

Keywords

Cytomembrane-based vesicles; Bacterial resistance; Antibacterial therapy; Drug delivery

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