New horizons for therapeutic applications of nanozymes in oral infection (Open Access)--颗粒学报PARTICUOLOGY

Cai, Y., Li, Y., Zhang, J., Tang, N., Bao, X., & Liu, Z. (2023). New horizons for therapeutic applications of nanozymes in oral infection. Particuology, 80, 61-73. https://doi.org/10.1016/j.partic.2022.12.002

New horizons for therapeutic applications of nanozymes in oral infection (Open Access)

Yanting Cai ^a, Yue Li ^a, Jin Zhang ^b, Nan Tang ^b, Xingfu Bao ^a *, Zhen Liu ^b *

a Department of Orthodontics, Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, School and Hospital of Stomatology, Jilin University, Changchun, 130021, China
b Beijing Advanced Innovation Center for Soft Matter Science and Engineering, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing, 100029, China

10.1016/j.partic.2022.12.002

Volume 80, September 2023, Pages 61-73

Received 1 November 2022, Revised 29 November 2022, Accepted 9 December 2022, Available online 19 December 2022, Version of Record 1 March 2023.

E-mail: baoxf@jlu.edu.cn; liuganxuan@mail.buct.edu.cn

Highlights

• Nanozymes have attracted admirable attention in various biomedical fields.

• Nanozymes have been well developed as efficient therapeutic agents in oral infection.

• Nanozymes reveals great potential for more oral diseases in further clinical setting.

Abstract

As a category of nanomaterials with excellent catalytic efficiency, great substrate specificity, and high recovery efficiency, nanozymes have attracted increasing attention in various biomedical applications. Currently, numbers of nanozyme-assisted strategies have been well developed for the theranostics of various diseases by taking advantages of their multienzyme-like characteristics, low cost, and high stability. As the most prevalent oral diseases, oral infection poses a global hazard to human health, and current therapeutic options are insufficient to resolve all the clinical issues. Based on their admirable activity, nanozymes can be frequently employed in the identification and treatment of various oral infectious disorders. Herein, we provide a brief review focused on the classification of nanozymes, analyses of nanozyme-based antibacterial mechanism, research progress in oral bacterial control, and representative studies of nanozyme-assisted oral inflammatory management. Moreover, major challenges and potential opportunities regarding the use of nanozymes in oral infectious diseases are also highlighted and discussed. This review not only summarizes the recent studies of nanozymes in oral infection but also promotes the further development of enzyme-mimetic strategies towards various oral diseases.

Graphical abstract

Keywords

Nanozymes; Oral infection; Antibacterial therapy; Anti-inflammatory therapy

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