Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery (Open Access)--颗粒学报PARTICUOLOGY

Ye, T., Zou, L., Wang, Y., & Ma, G. (2023). Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery. Particuology, 80, 53-60. https://doi.org/10.1016/j.partic.2022.11.015

Engineered self-healing single-cavity microcapsules for pulsatile release of drug delivery (Open Access)

Tong Ye ^{a b d}, Lingjiao Zou ^{a c}, Yishu Wang ^{a b}, Guanghui Ma ^{a b d *}

a State Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, China
b School of Chemical Engineering, University of Chinese Academy of Sciences, Beijing, 100049, China
c Division of Molecular Science, Graduate School of Science and Technology, Gunma University, 1-5-1, Tenjin-cho, Kiryu, 376-8515, Japan
d Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing, 100190, China

10.1016/j.partic.2022.11.015

Volume 80, September 2023, Pages 53-60

Received 9 November 2022, Revised 23 November 2022, Accepted 25 November 2022, Available online 5 December 2022, Version of Record 1 March 2023.

E-mail: ghma@ipe.ac.cn; tye@ipe.ac.cn

Highlights

• A series of self-healing single-cavity microcapsules with different release profiles.

• A flexible collocation strategy of microcapsules to achieve customized pulsatile drug release.

• A drug delivery system contains only PLGA, holding great promise for clinical translation.

Abstract

A wide range of polymer-based drug delivery systems have been reported for the treatment of various diseases. However, the dosing regimen of many drugs, such as stimulator of interferon genes agonists, programmed cell death protein-1 antibodies, and coronavirus disease 2019 vaccines, consists of repeated intratumoral or intramuscular injections. These repeated administrations may lead to poor adherence, thus resulting in compromised therapeutic outcomes and increased financial burden. Here, we developed a multidose drug delivery platform by engineering polylactic-co-glycolic acid (PLGA) with different molecular weights into self-healing single-cavity microcapsules (SSM). This approach showed a flexible collocation strategy to achieve customized pulsatile drug release and was fully degradable with good safety. Notably, this single-injection delivery system contains only PLGA, holding great promise for clinical translation.

Graphical abstract

Keywords

Drug delivery; Single-cavity microcapsule; Pulsatile release; Self-healing microparticle

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