Biotransformation, multifunctional recycling mechanism of nanostructures, and evaluation of the safety of nanoscale materials--颗粒学报PARTICUOLOGY

Talukdar, D., Kumar, P., Chaudhary, B., Sharma, D., Yadav, N., Afzal, O., . . . Gupta, M. M. (2023). Biotransformation, multifunctional recycling mechanism of nanostructures, and evaluation of the safety of nanoscale materials. Particuology, 82, 76-86. https://doi.org/10.1016/j.partic.2023.01.009

Biotransformation, multifunctional recycling mechanism of nanostructures, and evaluation of the safety of nanoscale materials

Debjyoti Talukdar ^a, Parveen Kumar ^b, Benu Chaudhary ^c, Deepak Sharma ^d, Nishant Yadav ^e, Obaid Afzal ^f, Abdulmalik Saleh Alfawaz Altamimi ^f, Waleed Hassan Almalki ^g, Sami I. Alzarea ^h, Imran Kazmi ⁱ, Ashutosh Pareek ^j, Gaurav Gupta ^{k l m}, Madan Mohan Gupta ⁿ

a Department of Medical Research, Armenian Russian International University “Mkhitar Gosh”, Yerevan, Armenia
b Shri Ram College of Pharmacy, Karnal, Haryana, India
c Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
d Department of Pharmaceutical Technology, SOMS, Adamas University, Barasat- Barracpore Road, Kolkata, West Bengal, India
e B.S. Anangpuria Institute of Pharmacy, Faridabad, Haryana, India
f Department of Pharmaceutical Chemistry, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al Kharj, 11942, Saudi Arabia
g Department of Pharmacology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia
h Department of Pharmacology, College of Pharmacy, Jouf University, Sakaka, Al-Jouf, Saudi Arabia
i Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia
j Department of Pharmacy, Banasthali Vidyapith, Banasthali-Rajasthan, India
k School of Pharmacy, Suresh Gyan Vihar University, Jagatpura, 302017, Mahal Road, Jaipur, India
l Department of Pharmacology, Saveetha Dental College, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India
m Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
n School of Pharmacy, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago

10.1016/j.partic.2023.01.009

Volume 82, November 2023, Pages 76-86

Received 21 November 2022, Revised 31 December 2022, Accepted 18 January 2023, Available online 1 February 2023, Version of Record 10 February 2023.

E-mail: mmgupta1432@gmail.com

Highlights

• Nanoparticle biodistribution and toxicity need a multifunctional recycling system.

• Recycling strategies should be implemented to control the nanoparticle's exposure body.

• Long-term fate in the body is crucial, as it governs environmental risks to health.

Abstract

Current evidence of concept analyses recommending nanotechnology for biomedical uses abounds in recent research. The area of biotechnology interfaces with nanostructures, reconfigures their composition, and alters their characteristics; which influences the dispersion of the particles, the biotransformation they cause, and their potential toxic effect. It is vital to link the idea of the lifecycle of nanostructures to the biological impacts and use methodologies to identify, estimate, and track the gradual bioprocessing of nanostructures in vivo, from a body-wide level to a nanoscopic size. This is necessary because understanding how nanostructures processing, degradation, persistence, and recycling predict potential exposure risks. The safe implementation of nanotechnology-based products in biomedical applications necessitates an extensive understanding of the recycling and transformations of nanomaterials in a living organism. Long-term fate in the body is crucial, as it governs potential environmental risks to human health. Strategies may be used to manage the long-term outcome of nanostructures in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. The lifespan of nanoparticles, a flexible and biocompatible category of nanostructures that have made it into clinical trials, is the subject of this article. Strategies may be used to manage the long-term outcome of nanoparticles in an organism since, in addition to composition, their design also affects how long they last and how easily they degrade. This review explained the safety of nanoscale materials, biotransformation, and the multifunctional recycling mechanism of nanostructures.

Graphical abstract

Keywords

Nanostructure; Nanoparticle; Biotransformation; Toxic effect; Environmental risk

文章导读