Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release--颗粒学报PARTICUOLOGY

Meng, Q., Zhong, S., Wang, J., Zhang, Z., Gao, Y., & Cui, X. (2024). Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release. Particuology, 84, 168-177. https://doi.org/10.1016/j.partic.2023.06.006

Sono-assembly of folate-decorated curcumins/alginate core-shell microcomplex and its targeted delivery and pH/reduction dual-triggered release

Qingye Meng^a, Shuangling Zhong^b, Jingfei Wang^a, Zhenqian Zhang^a, Yan Gao^{a c d *}, Xuejun Cui^{a d *}

a College of Chemistry, Jilin University, Changchun, 130012, China
b College of Resources and Environment, Jilin Agricultural University, Changchun, 130118, China
c State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun, 130012, China
d Weihai Institute for Bionics-Jilin University, Weihai, 264400, China

10.1016/j.partic.2023.06.006

Volume 84, January 2024, Pages 168-177

Received 20 December 2022, Revised 4 May 2023, Accepted 6 June 2023, Available online 22 June 2023, Version of Record 28 June 2023.

E-mail: gaoy@jlu.edu.cn; cui_xj@jlu.edu.cn

Highlights

• Sodium alginate-based microcapsules prepared by economical sonochemical method.

• Microcapsules have high encapsulation rate and good biocompatibility.

• Excess Curcumin (CUR) and ethyl acetate can be recycled and reused.

• CUR-loaded microcapsules (FA-RSMCs@CUR) exhibit good antibacterial properties.

• FA-RSMCs@CUR exhibit targeted and pH/reduction dual-triggered release properties.

Abstract

In this study, sodium alginate (SA), a non-toxic natural polysaccharide with good biocompatibility and biodegradability, was developed for targeted delivery of curcumin (CUR) in tumor therapy. The strategy is to sulfhydrylate the folic acid (FA) modified SA, and the CUR dissolved in ethyl acetate (EAC) phase is coated in microcapsules by a quick, efficient and environment-friendly sonochemical method. The EAC in the microcapsule core is volatile, which can be recycled and reused to reduce cost. The prepared microcapsules (FA-RSMCs@CUR) exhibited similar toxicity to free curcumin in anti-tumour evaluation in vitro. FA-RSMCs@CUR also exhibited effective antibacterial properties in the antibacterial evaluation in vitro. It is expected to become a low-cost tumor targeting vector in the future, and has the potential to be promoted in clinical application.

Graphical abstract

Keywords

Reductive-responsive; Sodium alginate; Microcapsule; Targeted delivery; Sonochemical

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