Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor (Open Access)--颗粒学报PARTICUOLOGY

Xu, S., Wu, J., Ren, Z., & Niu, D. (2024). Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor. Particuology, 85, 113-121. https://doi.org/10.1016/j.partic.2023.04.001

Precise phase adjustment and antibacterial property of copper sulfide particles in confined mesoporous silica nanoreactor (Open Access)

Shiyu Xu, Jinyong Wu, Zhongzhen Ren, Dechao Niu ^*

Low Dimensional Materials Chemistry Laboratory, Key Laboratory for Ultrafine Materials of Ministry of Education, Frontier Science Center of the Materials Biology and Dynamic Chemistry, Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, 200237, China

10.1016/j.partic.2023.04.001

Volume 85, February 2024, Pages 113-121

Received 18 February 2023, Revised 1 April 2023, Accepted 9 April 2023, Available online 15 April 2023, Version of Record 25 April 2023.

E-mail: dcniu@ecust.edu.cn

Highlights

• Cu_xS_y@DMSNs is prepared by a confined in situ sulfurization method.

• Crystal phase of Cu_xS_y can be controlled by changing sulfurization temperature.

• CuS@DMSNs have high NIR-Ⅱ photothermal conversion efficiency of 36.86%.

• Peroxidase-like activity of CuS@DMSNs can be enhanced by photothermal exposure.

• CuS@p-DMSNs shows good antibacterial properties with 1064 nm NIR and H₂O₂.

Abstract

Bacteria-caused wound infection greatly threatens human health, thus developing an efficient and safe antibacterial agent without drug resistance is still a great challenge. Herein, a confined vulcanization strategy is proposed to construct copper sulfides-loaded dual-mesoporous silica nanospheres (Cu_xS_y@DMSNs) with various crystal phases for reactive oxygen species (ROS)-mediated and photothermal antibacterial application. With the pore confinement of DMSNs, the crystal phases of copper sulfides including CuS, Cu₉S₅ and Cu_1.96S can be easily controlled by changing the vulcanization temperature. The relationships between the crystal phases and photothermal properties as well as peroxidase-like activity of copper sulfides were systematically investigated. Results show that the obtained CuS@DMSNs exhibited higher photothermal ability with remarkable photothermal conversion efficiency of 36.86% in the second near-infrared region (NIR-II) and better peroxidase-like activity, compared to those of Cu₉S₅@DMSNs and Cu_1.96S@DMSNs. As a result, the in vitro experiments showed the good antibacterial effect against both gram-negative E. coli and gram-positive S. aureus under 1064 nm laser irradiation and the presence of H₂O₂. Besides, the CCK-8 assay indicated that CuS@p-DMSNs have minimal cytotoxicity against normal human umbilical vein endothelial cells at the ranged concentrations. Therefore, the resultant CuS@p-DMSNs could act as a promising antibacterial agent for deep wound bacterial infection treatment.

Graphical abstract

Keywords

Copper sulfides; Mesoporous silica; Photothermal; Reactive oxygen species; Antibacterial agent

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